中文摘要：

腺病毒载体是最早用于基因治疗研究的病毒载体之一，也是目前肿瘤基因治疗中最为常见的病毒载体之一，其主要通过靶细胞表面的天然柯萨奇腺病毒受体（coxsackie and adenovirus receptor，CAR）感染宿主细胞。由于大多数肿瘤细胞表面该受体表达水平较低，降低了腺病毒载体对靶细胞的感染效率，从而制约了腺病毒载体在肿瘤基因治疗中的应用。因此，如何提高腺病毒载体对靶细胞的感染效率是腺病毒载体应用于肿瘤基因治疗的关键。目前对腺病毒载体衣壳蛋白质（capsid Protein）的遗传修饰是提高其对宿主细胞感染效率的主要途径。本文将对这一领域的主要研究进展作一综述，为该方面的研究提供有用的信息。

英文摘要：

Adenoviral vector （Ad） is one of the earliest viral vectors used for gene therapy and is also one of the most common viral vectors for tumor gene therapy so far. Ad infects target cells mainly through the native receptor （coxsackie and adenovirus receptor, CAR） present on the cell surface of the target cells. Due to the lack of Ad receptor on the cell surface of most cancer cells, adenoviral infection efficiency of target cell is low, which limits the therapeutic effect of adenoviral vectors for tumor gene therapy. Therefore, how to improve adenoviral infection efficiency of target cell will be critical for adenoviral vector used in the tumor gene therapy. Genetic modification of adenoviral capsid is the major approach to improve adenoviral infection efficiency. The article summarizes the main progress on the study in this field, which will provide useful information for this study.