中文摘要：

卵泡发育是受内分泌、旁分泌及基因调节的复杂生理过程。条件基因敲除能选择去除调控特定发育阶段特定细胞或器官的基因，是在体基因功能研究的主要手段。近年来该技术被广泛应用于卵泡发育调控机制的研究。本文综述了条件基因敲除技术在始基卵泡激活、卵母细胞成熟、排卵、黄体形成及早期胚胎发育等机制研究中的应用进展。

英文摘要：

Follicular development is a complicated physiological processes regulated by endocrine, paracrine and gene. Conditional knockout approach can remove a gene at a specific cells or organs. This technology can help us to clarify gene functions in vivo. In recent years, the conditional knockout is widely applied to study the follicular regulatory mechanism. In this review, we have summarized recent progress in molecular mechanisms regulating activation of primordial follicles, oocyte meiotic maturation, ovulation, and luteinization as revealed by conditional knockout technology in the mouse ovary.