中文摘要：

为了研究冷驯化条件下中缅树鼩Tupaia belangeri的脂肪组织是否会转化,本研究测定了冷驯化条件下中缅树鼩脂肪组织质量,脂肪转化因子过氧化物酶体增殖激活受体α（PPARα）、环氧化酶-2（COXⅡ）及过氧化物酶体增殖物受体γ共激活因子1α（PGC-1α）基因表达量的变化。结果表明：中缅树鼩冷驯化组无论是褐色脂肪组织（BAT）质量,还是大网膜白色脂肪组织（WAT）质量均较对照组显著增加（P〈0.01）,脂肪转化因子PPARα、COXⅡ及PGC-1α基因表达量也显著上调（P〈0.01）。以上结果说明中缅树鼩WAT中PPARα、COXⅡ、PGC-1α基因表达量的增加可能诱导了WAT细胞褐变,进而向BAT细胞转化和提高BAT中解偶联蛋白1的表达。

英文摘要：

In order to investigate whether the adipose tissue of Tupaia belangeri would be transformed under cold acclimation,the mass of adipose tissue,changes of peroxisome proliferator-activated receptor α（ PPARα）,cyclooxygenase-2（ COXⅡ） and peroxisome proliferators-activated receptor-γ coactivator-1（ PGC-1α） genes were measured in the present study. The results showed that mass of brown adipose tissue and omental white adipose tissue,the m RNA expressions of PPARα,COXⅡ and PGC-1α genes were increased extreme significantly under cold exposure compared with control（ P〈0. 01）. And these indicated that the increased expressions of PPARα,COXⅡ and PGC-1α genes under cold condition may cause the transformation of white adipose tissue to browning beige adipocyte,which then transformed to brown adipose tissue and increase the level of uncoupling protein 1 in brown adipose tissue.