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0.2μm Al2O3陶瓷膜微滤杞菊地黄丸水提液的污染机理及清洗研究
  • ISSN号:1001-1528
  • 期刊名称:《中成药》
  • 时间:0
  • 分类:R284.2[医药卫生—中药学;医药卫生—中医学]
  • 作者机构:[1]南京中医药大学植物药深研究与开发中心,江苏南京210029
  • 相关基金:国家自然科学基金项目(30171161);国家中医药管理局中医药科学技术研究专项,(02-03ZP33)
中文摘要:

目的:对0.2μmAl2O3陶瓷微滤膜过滤杞菊地黄丸水提液过程中膜污染机理进行研究,并寻找有效的膜清洗方法。方法:以杞菊地黄丸水提液为研究对象,根据Darcy-Poiseuille定律这一过滤模型确定过滤阻力分布情况,同时对污染膜表面和截面的进行高分辨扫描电镜观测。结果:①对于本体系,膜阻力主要集中在表面沉积层,膜本身的阻力及浓差极化层阻力起了次要作用,膜孔内部污染阻力所占比例最小。并且,这与通过对SEM图像的分析所得到的结果大致相吻合。②本体系采用了超声、NaOH溶液清洗、HCl溶液清洗、NaOH溶液清洗的清洗步骤,膜的渗透通量基本可以完全恢复。结论:根据膜污染机理的不同,选用适用的清洗剂再生方法,这对于对上业化生产有一定的指导意义。

英文摘要:

AIM: To discuss the fouling mechanism of 0. 2 μm Al2O3 ceramic membrane in the microfiltation of extraction of Qijudihuang Pills, and obtain the effective cleaning proeotrol. METHODS: The extract of Qijudi-huang Pills microfiltered and the distributions of filtration resistance were studied according to the Darcy-Poiseuille principle. The characteristic of the surface and section of the polluted membrane were analysed by SEM also. RE- SULTS: ① For the main body, the filtration resistance was mainly decided by the deposit resistance, the membrane itself and the concentration polarization resistance were less important, and the pore blocking resistance was minimum. Moreover, this result was proved by the analysis of SEM. ② The effective four-step cleaning procotrol, which could almost recover original membrane flux, was achieved by three cleaner, including ultrasound, NaOH solution and HCl solution. CONCLUSION: Based on the different fouling mechanism, the appropriate cleaning procotrol can be obtained. This provides great significance for the application of the industrialized manufacture.

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期刊信息
  • 《中成药》
  • 北大核心期刊(2011版)
  • 主管单位:
  • 主办单位:国家食品药品监督管理局 信息中心中成药信息站
  • 主编:陶建生
  • 地址:上海市黄浦区福州路(近江西中路)107号206室
  • 邮编:200002
  • 邮箱:zcy.med@foxmail.com
  • 电话:021-63213275
  • 国际标准刊号:ISSN:1001-1528
  • 国内统一刊号:ISSN:31-1368/R
  • 邮发代号:4-249
  • 获奖情况:
  • 首届中国学术期刊《CAJ-CD规范》优秀期刊
  • 国内外数据库收录:
  • 美国化学文摘(网络版),中国中国科技核心期刊,中国北大核心期刊(2004版),中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版),中国北大核心期刊(2000版)
  • 被引量:62184