中文摘要：

目的：回顾性总结及分析肾上腺淋巴瘤患者的临床特点及预后。方法：收集本中心2002-01-2013-12收治的肾上腺淋巴瘤患者共18例,其中包括原发性肾上腺淋巴瘤（PAL）10例,继发性肾上腺淋巴瘤（SAL）8例。随访终点时间为2014年3月30日。生存分析采用Kaplan-Meier方法,Log-rank方法进行组间比较。结果：在病理亚型上,无论是PAL还是SAL,均以弥漫大B细胞淋巴瘤最多见,其次为外周T细胞淋巴瘤非特指型。在临床表现上,2组患者最常见的症状类似,均为B症状、乏力、腰背部局部不适感、纳差等。SAL患者肝脾肿大和Ann Arbor分期Ⅲ/Ⅳ期较多见（P=0.019和P=0.036）。无论是PAL还是SAL,患者的总生存时间差异无统计学意义。IPI评分≥3分或T细胞来源的淋巴瘤,患者生存时间显著缩短（P=0.049 5,P=0.003 4）。结论：肾上腺淋巴瘤缺乏特异的临床表现,以弥漫大B细胞淋巴瘤最多见。IPI≥3分或T细胞来源,患者的生存时间显著缩短。由于本研究的病例数较少,仍需要大规模的前瞻性研究来验证。

英文摘要：

Objective：To analyze the clinical characteristics and survival of patients with adrenal lymphoma. Method：Clinical datas of 18 adrenal lymphoma patients treated in our hospital from January 2002 to December 2013 were collected and analyzed. Among them,10 cases were primary adrenal lymphoma （PAL） and 8 cases were sec- ondary adrenal lymphoma （SAL）. The date of last follow-up was March 30,2014. Survival functions were esti- mated using the Kaplan-Meier method and compared by the Log-rank test. Result：Both in PAL and SAL,the main subtype of the adrenal lymphoma was diffuse large B-cell lymphoma,followed by peripheral T cell lymphoma-not otherwise specified. The major symptoms,in both PAL and SAL, were B symptom, fatigue, regional pain,and ano- rexia. Hepatosplenomegaly and advanced stage were more frequent in SAL than in PAL （P= 0. 019 and P= 0. 036, respectively）. Considering the patients overall survival （OS）, there was no statistical difference between PAL and SAL. But patients with IPI score≥3 or T-cell derived lymphoma had shorter OS （P=0. 049 5 and P=0. 003 4 ,respectively）. Conclusion：The most common subtype of adrenal lymphoma is diffuse large B-cell lymphoma and pa- tients lack specific symptoms. Patients with IPI score≥3 or T-cell derived lymphoma have poor outcome. Because of the limited number of patients, the prospective multi-center clinical analysis is warranted.