中文摘要：

成熟 T 房间淋巴的恶意包括在 clinicopathological 特征，生物行为，治疗反应，和预后变化的一组异构的疾病。骨头髓(BM ) 渗入与他们的 B 房间对应物相比在成熟 T 房间淋巴的恶意是更通常在场的并且为微分诊断因此重要。在这研究，临床的特征和预示的因素在 225 个病人被分析，成熟 T 房间淋巴的恶意在一个单个机构对待。这些包括了 T 房间 lymphoproliferative 混乱的 29 个盒子(T-LPD，都与 BM 渗入) 并且 T-/natural-killer-cell 淋巴瘤的 196 个盒子(T/NKCL， 56 与 BM 渗入并且 140 没有 BM 渗入) 。T-LPD 和 T/NKCL 的估计的 5 年的全面幸存(OS ) 率分别地是 96.6% 和 37.3% 。T-LPD 病人多半是更少展出差的表演地位，先进疾病阶段， B 症状的存在，或浆液 -2 microglobulin 的反常水平。与类似的病理学的特征，没有 BM 渗入，有渗入显示出的 BM 的 T/NKCL 病人显著地比那些降低反应率和更短的 OS (P = 0.0264 并且 P < 0.0001，分别地) 。Multivariate 分析显示了那差的表演地位，先进疾病舞台，提高的浆液喂奶脱氢酶水平，和 BM 参与是独立相反的预示的因素。格拉斯哥预示的分数可能是比在在 T/NKCL 预言疾病结果的国际预示的索引更有效的。在结论，临床的特征可能在有成熟 T 房间淋巴的恶意的更有效地成层的病人是有用的。

英文摘要：

Mature T-cell lymphoid malignancies comprise a group of heterogeneous diseases that vary in clinicopathological features, biological behavior, treatment response, and prognosis. Bone marrow （BM） infiltration is more commonly present in mature T-cell lymphoid malignancies compared with their B-cell counterparts and hence important for differential diagnosis. In this study, clinical characteristics and prognostic factors were analyzed in 225 patients with mature T-cell lymphoid malignancies treated in a single institution. These included 29 cases of T-cell lymphoproliferative disorders （T-LPD, all with BM infiltration） and 196 cases of T-/natural-killer-cell lymphoma （T/NKCL, 56 with BM infiltration and 140 without BM infiltration）. The estimated 5-year overall survival （OS） rates of T-LPD and T/NKCL were 96.6% and 37.3%, respectively. T-LPD patients were less likely to exhibit poor performance status, advanced disease stage, presence of B symptoms, or abnormal level of serum [~-2 microglobulin. With similar pathological characteristics, T/NKCL patients with BM infiltration showed significantly lower response rates and shorter OS than those without BM infiltration （P = 0.0264 and P 〈 0.0001, respectively）. Multivariate analysis indicated that poor performance status, advanced disease stage, elevated serum lactate dehydrogenase level, and BM involvement were independent unfavorable prognostic factors. The Glasgow Prognostic Score may be more efficient than the International Prognostic Index in predicting disease outcome in T/NKCL. In conclusion, clinical characteristics may be useful in more effectively stratifying patients with mature T-cell lymphoid malignancies.