中文摘要：

目的探讨2型糖尿病周围神经病变（DPN）患者外周血白细胞介素6（IL-6）的改变及其临床意义。方法选取100例2型糖尿病患者，分为糖尿病周围神经病变组（DPN组）50例和无糖尿病周围神经病变组（NDPN组）50例，另选择50例健康人群作为对照组（NC组）。测定外周血IL_6含量，比较三组间IL-6水平差异；应用Pearson相关分析，探讨影响血清IL-6浓度的相关影响因素；应用Logstic回归分析，了解DPN发病的独立影响因素。结果（1）T2DM纽IL-6水平显著高于NC组，DPN组IL-6水平显著高于T2DM组（均P〈0．01）；（2）Pearson相关分析显示，血清IL-6水平与运动及感觉神经传导速度均呈负相关（r值分别为-0．488，-0．389，均P〈0．05），与胰岛功能指数呈负相关（r=-0．384，P〈0．01）。Logistic回归分析发现体质量指数、收缩压、IL-6为DPN发病的独立危险因素。结论2型糖尿病并发周围神经病变患者外周血IL-6水平明显增加，与DPN发病密切相关。

英文摘要：

Objective To explore the changes of serum interleukin 6 （IL-6） levels in patients with type 2 dia- betes peripheral neuropathy （DPN） and its clinical significance. Methods A total of 100 patients with type 2 diabetes were divided into diabetic peripheral neuropathy （DPN）group （50 cases）and non-diabetic peripheral neuropathy （NDPN） group（50 cases）. In addition,50 cases of healthy people were selected as control group （NC group）. The ser- um level of IL-6 were detected and compared among three groups. Pearson correlation analysis was used to explore which factors influence on the serum level of IL-6. Logistic regression analysis were carried out to evaluate the independent in- fluencing factors of DPN. Results （ 1 ） Serum level of IL-6 was higher in NDPN group than that in NC group , Serum level of IL-6 was higher in DPN group than in NDPN group （P 〈0.01 ）. （2） Pearson correlation analysis showed that the serum level of IL-6 was negatively correlated with both motor and sensory nerve conduction velocity （ r = - 0. 488, r = -0.389 ,respectively,P 〈 0.05 ）, and also negatively correlated with islet function index （r = -0.384 ,P 〈 0.01 ）. Logistic analysis showed that body mass index, systolic blood pressure and IL-6 were independent risk factors for DPN. Conclusion The levels of IL-6 are increased significantly in patients with type 2 diabetes peripheral neuropathy and closely related to the development of DPN.