中文摘要：

系统性红斑狼疮（SLE）是一种典型的系统性自身免疫性疾病，以多器官受累和多系统损害为特点，I临床表现、病程发展及病情转归均具有较大的个体差异。与一般人群相比，SLE患者合并恶性肿瘤的发生率及进展速度显著增加，常见恶性肿瘤类型有非霍奇金淋巴瘤（NHL）、子宫颈癌以及支气管肺癌等。遗传易感性、慢性抗原刺激、过度自身免疫反应及免疫抑制剂的长期使用，可能是SLE患者恶性肿瘤发生率升高的原因。本文对SLE患者常见各种合并恶性肿瘤的分子病理学、流行病学及临床方面的研究进展进行综述。

英文摘要：

Systemic lupus erythematosus （SLE） is a prototypical systemic autoimmune disease, characterized by a wide array of symptoms and organ involvements, leading to varying disease courses and outcome, and ranging from mild to severe types. In patients with SLE, the incidence and risk of malignancy development is increased, and non-Hodgkin＇ s lymphoma （NHL）, cervical cancer, as well as bronchial carcinomas occur, are common malignancy types. Common genetic predisposition, chronic antigen stimulus, disproportional immune respon- ses, as well as the chronic administration of immunosuppressive medications can contribute to the develop- ment of malignancies in SLE patients. In this review we present some research areas such as the molecular pathology, epidemiological and clinical of the malignancies in SLE patients population.