中文摘要：

目的分析抗核小体抗体（AnuA）与系统性红斑狼疮（SLE）患者临床特征及其活动性的相关性。方法采用回顾性研究并用调查表的形式收集694例AnuA阳性患者临床资料，并与733例An—uA阴性病人进行比较分析。结果AnuA与蝶形红斑、光敏感、关节炎、心包炎及狼疮性肾炎的发生相关（P〈0．05）；AnuA阳性可伴有其他自身抗体及免疫学指标异常出现；AnuA阳性与肾脏损害指标血尿、蛋白尿、管型尿及尿素氮的发生率明显相关（P〈0．05）；AnuA阳性与系统性红斑狼疮疾病活动性指数（SLEDAI）相关（P〈0．05）。结论AnuA可能是SLE的又一标志性抗体，其检测可用于疾病的早期诊断，有助于SLE疾病活动度、严重程度及狼疮肾炎（lupus nephritis，LN）的判断。

英文摘要：

Objective To study the relation of Anti-nucleosome antibodies （AnuA） with both clinical features and disease activity of patients with systemic lupus erythematosus（SLE） in Chinese Han. Methods We have retrospectively reviewed the clinical data of 694 SLE patients with positive AnuA by questionnaire, and compared them with 733 SLE with negative AnnA. Results AnuA were significantly correlated with the prevalence of malarrash, photosensitivity, arthritis, pericarditis and LN in SLE patients （ P 〈 0.05 ）. They were more likely coexisted with other serological abnormalities including antinuclear antibodies. AnuA were significantly associated with the index of kidney damage such as hematuria, proteinuria, urinary casts and BUN（P 〈 0.05 ）. The SLE Disease Activity Index （SLEDAI） score was signifificant difference between the two groups （ P 〈 0.05）. Conclusion AnuA may be a well marked antibody for SLE. Detection of AnuA may be a useful tool for diagnosis of SLE in early stages and contribute to judging diseases activity and Iupus nephritis.