中文摘要：

文章在界定“主病主方”与专病专方和多病通治方内涵的基础上，对主病主方的制方思路、运用模式作了系统论述。指出主病主方是高度针对贯穿整个疾病始终的主导病机，以一方为主，并可根据病情、证候、体质的多样性，据主方加味，体现病一体一证一统观。其有别于一病一方的专病专方，也异于一方可治多病的通治方。主病主方的制方思路大抵为审机制方、专病专药、辨体制方、移植成方、组合小方、新拟验方等。其运用模式有主方加减、合方分击、调体用方、序贯用方。文后附2则案例加以论证。

英文摘要：

This essay systematically discussed the creation idea and application mode of ＇main disease-main prescription＇on the basis of defining the connotation of ＇main disease-main prescription＇ ＇specific disease-specific prescription＇ and ＇prescriptions that can cure many diseases＇.It also pointed out that ＇main disease-main prescription＇ is aimed at the main pathogenesis through the whole course of disease, and one prescription is used as the main prescription, modified according to the state of illness, syndrome and constitution of patients .It reflects the view of uniform of disease, constitution and syndrome. It differed from＇specific disease-specific prescription＇ and prescriptions that can cure many diseases. Its creation idea mainly includes discriminating pathogenesis, differentiating constitutions, transplantation, combination and creation. Its application mode includes main prescription-plus ＆ minus, jointed prescriptions-dissemble, constitution regulation prescription and sequential prescription. 2 cases were attached in the back part of the text for further demonstration.