中文摘要：

目的：探讨高场磁共振扩散成像表观扩散系数（ADC ）值与纤维化含量、成纤维细胞活化蛋白（FA P ）表达评分的相关性。方法对18例经病理证实的胰腺癌患者进行3．0T MRI平扫及扩散加权成像（DWI）扫描，使用单一层面法选取感兴趣区（ROI）测量癌区ADC值，并对胰腺癌患者的蜡块进行Masson染色及FAP免疫组化染色，采用 Pearson相关分析检验ADC值与纤维化含量、FA P染色评分的相关性。结果胰腺癌区的ADC值与纤维化含量呈负相关（ r＝－0．459），但无统计学意义（ P＝0．056），中～高分化组ADC值与纤维化含量呈负相关（ r＝－0．564，P＝0．044）。ADC值与 FA P染色评分呈负相关（ r＝－0．479，P＝0．036）。结论胰腺癌的ADC值与其病理参数间呈负相关，DWI有望对胰腺癌的病理特征实现定量成像，有助于进一步了解其病理特征。

英文摘要：

Objective To investigate the correlations of apparent diffusion coefficient （ADC） with fibrosis and fibroblast activation protein （FAP） score in pancreatic cancer .Methods Eighteen patients with pathologically confirmed pancreatic cancer were per‐formed conventional MR imaging ,DWI examinations .ADCs were measured with region of interest method on a “Single slice” .The wax blocks of 18 patients with pancreatic cancer were received Masson staining and FAP immunohistochemical staining .The correla‐tions of ADC with levels of fibrosis and FAP scores of pancreatic cancer were assessed by Pearson correlation analysis .Results The mild negative correlation between ADC value of cancerous foci and fibrosis was not significant （r= -0 .459 ,P=0 .056） .Significant negative correlation was found between ADC values of moderate and high differentiation cancerous foci and fibrosis （r= -0 .564 ,P=0 .044） .Significant negative correlation was found between ADC value and FAP score （r= -0 .497 , P=0 .036） .Conclusion The negative correlations are found between ADC and fibrosis ,FAP score of pancreatic cancer .DWI will be helpful to infer the pathologi‐cal characteristics .