中文摘要：

目的：目前判断急性胰腺炎预后的预测方法的准确度尚不能满足临床需要。本研究通过将5级肠功能衰竭（GIF）评分系统与SOFA评分系统结合,探讨GIF评分系统在急性胰腺炎预后中的价值。方法：回顾性分析2008年9月～2012年4月在西京消化病医院重症监护室住院的241例急性胰腺炎病例资料。计算患者入院后前3天的SOFA及GIF评分。应用受试者工作曲线下面积（AUC）比较GIF评分、SOFA评分及SOFA联合GIF评分（联合评分）对急性胰腺炎预后的判断价值。结果：235例患者纳入最终分析。死亡率随着入院后前3天GIF评分均值的升高而增加。联合评分有最大的AUC（0.849）,显著高于单独使用SOFA评分（0.793,P=0.002）,GIF评分的AUC是0.812。入院后前3天内发生肠功能衰竭和未发生肠功能衰竭的患者入院后30天内的的死亡率分别是45.5%和5.2%（log-rank test=60.306;P=0.000）。结论：GIF评分可用于对急性胰腺炎预后的评估,GIF评分与SOFA评分联合应用对预后判断的准确度高于单独运用其中任一个。

英文摘要：

Objective： To our knowledge,the predictors for the prognosis of acute pancreatitis still can not satisfy clinical practice.This study was to investigate whether 5-grade scoring system for assessment of gastrointestinal function（the Gastrointestinal Failure scores） could be used to predict the mortality of patients with acute pancreatitis（AP）.Methods： Two hundred and forty-one patients with AP admitted into the intensive care unit of the Xijing Hospital of Digestive Diseases from September 2008 to April 2012 were studied retrospectively.SOFA scores and GIF scores for the first 3 days were calculated.The AUC of ROC was used to evaluate the ability of SOFA scores,GIF scores and the combination of SOFA and GIF scores in predicting the mortality of AP patients.Results： A total of 235 patients were included in the final analysis.A high mean GIF score during the first 3 days was associated with a high rate of mortality.The combination of SOFA and GIF scores had the greatest AUC（0.849）,significantly higher than SOFA scores（0.793,P = 0.002） alone.The AUC of GIF scores alone was 0.812.The development of gastrointestinal failure during the first 3 days was associated with significantly higher 30-days mortality（45.5% versus 5.2%,log-rank test = 60.306;P = 0.000）.Conclusions： The GIF scoring system is useful for predicting the AP prognosis.The combination of SOFA and GIF scores has a higher prognostic value than any one of them used alone.