中文摘要：

目的利用氢质子磁共振波谱分析肝细胞癌和胆管细胞癌代谢物变化。方法对正常对照组、病理证实的肝细胞癌和胆管细胞癌患者分别进行1．5T氢质子磁共振波谱检查，计算位于3．2ppm的胆碱峰（Cho）与位于1．3ppm的脂酯峰（Lip）的相对浓度（Cho／Lip）。结果正常肝脏、病理证实的胆管细胞癌及肝细胞癌的Cho／LIp分别为0．07±0．04、0．11±0．06和0．52±0．15．肝细胞癌的Cho／Lip显著高于正常对照和胆管细胞癌（P〈0．05），正常肝脏和胆管细胞癌的Cho／Lip差异无显著性（P〉0．05）。结论活体氢质子波谱分析可以从代谢水平反映肝细胞癌和胆管细胞癌病理变化情况，为临床诊断提供参考。

英文摘要：

Objective To investigate the value of in vivo proton magnetic resonance spectroscopy （ ^1 H MRS） in the assessment of hepatocellular carcinoma （HCC） and cholangiocarcinoma. Methods 1H MRS was performed in normal volunteers and in patients with pathologically confirmed HCC and cholangiocarcinomas using a whole-body 1.5-T scanner. The choline-to-lipid ratios were measured by dividing the peak area of choline at 3.2 ppm and lipid at 1.3 ppm. Results The ratio of choline-to-lipid for normal liver, cholangiocarcinomas, and HCC were 0.07 ± 0.04, 0. 11 ± 0. 06, and 0.52 ± 0. 15, respectively. The ratio of choline-to- lipid was significantly higher in HCC compared than those in cholangiocarcinomas or normal livers （ P 〈 0. 05 ） However, it was not significantly different between cholangiocarcinomas and normal livers （ P 〉 0.05 ）. Conclusion In vivo ^1H MRS can reflect the pathological changes of HCC and cholangiocarcinomas at metabolic level and thus is useful in the diagnosis of these two cancers.