中文摘要：

目的探讨心外膜脂肪组织（epicardial adipose tissue,EAT）与心房颤动（简称房颤）相关的血栓栓塞事件的关系。方法 2013年1月-2015年5月因行房颤射频消融手术于本院住院治疗的非瓣膜性房颤患者155例。使用螺旋CT扫描技术半手动测定患者总心外膜脂肪体积（EAT-total）及左心房周心外膜脂肪体积（EAT-LA）。根据既往有无房颤相关的缺血性脑卒中、短暂性脑缺血发作及体循环栓塞病史将研究对象分为栓塞组和对照组,比较两组各指标间的差异,探讨房颤患者心外膜脂肪组织与栓塞事件的关系。结果 155例中,22例纳入血栓栓塞组,平均年龄（62.50±10.42）岁,女性7例（28.6%）;余133例作为对照组,平均年龄（54.45±10.81）岁,女性38例（31.8%）。与对照组相比,血栓栓塞组EAT-total和EAT-LA体积明显增加[（123.49±31.25）cm^3 vs（100.71±35.04）cm^3,P=0.005;（34.58±6.32）cm^3 vs（26.89±9.65）cm^3,P〈0.001]。多元回归分析提示,在校正了年龄、高血压、糖尿病、血管性疾病等房颤血栓栓塞相关危险因素后,EAT-total和EAT-LA均与房颤患者栓塞事件独立相关。结论心外膜脂肪体积大小与房颤患者血栓栓塞事件相关,有成为预测房颤血栓栓塞风险新指标的潜在可能。

英文摘要：

Objective To investigate the relationship between epicardial adipose tissue（EAT） and thromboembolism event in patients with atrial fibrillation（AF）.Methods One hundred and fifty-five patients with non-valvular AF who were planning to undergo catheter ablation in our hospital from January 2013 to May 2015 were chosen.The total EAT volume（EAT-total）,atrial EAT volume（EATLA） were measured by CT.All patients were divided into two groups（thromboembolism group and control group） based on whether they had ischemic stroke,transient ischemic attack,or the history of thromboembolism related to AF,then the parameters between the two groups were compared and the relationship between epicardial adipose tissue and thromboembolism event in patients with atrial fibrillation were evaluated.Results Of the 155 patients,22（14%） had a history of thromboembolism and they were enrolled in thromboembolism group with average age of（62.50±10.42） years and 7 females（28.6%）.The other 133 patients were in control group with average age of（54.45±10.81） years and 38 females（31.8%）.Compared with control group,the EAT-total and EATLA in thromboembolism group increased significantly [（123.49±31.25） cm^3 vs（100.71±35.04） cm^3,P=0.005;（34.58±6.32） cm^3vs（26.89±9.65） cm^3,P〈0.001].After controlling for age,vascular disease,hypertension,diabetes and LA diameter,multivariable linear regression analysis showed that EAT-total and EAT-LA were independently associated with thromboembolism in patients with AF.Conclusion These results suggest that EAT may be an independent risk factor of thromboembolism in patients with AF.