中文摘要：

目的探讨低氧诱导因子-1α（HIF-1α）在原发性颊黏膜鳞癌中的表达变化及其意义。方法通过免疫组织化学方法，了解HIF-1α在60例原发性颊黏膜鳞癌中的表达，分析其阳性表达水平与颊癌临床分期、病理分级以及预后等临床病理因素之间的关系。结果不同分化程度的颊癌组织中HIF-1α的阳性表达水平差异没有统计学意义（P〉0．05）；而早、晚期颊癌组织中，HIF-1α阳性表达水平的差异存在统计学意义（P＜0．05）；有淋巴结转移的患者．其原发灶肿瘤组织中HIF-1α的阳性表达水平高于无淋巴结转移者（P〈0．05）；预后差的颊癌组织中，HIF-1α的阳性表达水平明显高于预后好组（P〈0．05）。结论颊癌中HIF-1α的阳性表达水平与疾病发展进程密切相关，其是颊癌患者预后不良的重要生物学指标。

英文摘要：

Objective To study the expression of hypoxia inducible factor-1α （HIF-1α） protein in buccal carcinoma and its biological significance. Methods The expression of HIF-1α was assayed by means of immunohistochemical technique in 60 patients. The expression of HIF-1α and its relationship with clinical pathological factors and tumor prognosis were investigated and analyzed statistically by Kruskal-Wallis Test. Results The positive rate of HIF-1α was higher in T3-4 than T1-2, and the positive rate of HIF-1α was higher in patients with cervical lymphatic metastasis than patients without cervical lymphatic metastasis. Patients with HIF-1α over-expression had poor prognosis than patients with HIF-1α lower expression. Conclusion Over-expression of HIF-1α is a vital biological marker in prognosis of buccal cancer.