中文摘要：

目的研究人舌鳞癌及正常黏膜中同源异型盒基因（Homeobox gene）的表达差异，认识该基因与舌鳞癌发生发展的关系。方法设立7组舌癌／癌旁组织标本，采用定制的含232条人类Homeobox基因探针的Oligo芯片进行分析，Agilent扫描仪扫描芯片结果，归纳两组间差异基因信息。结果在舌癌／癌旁组织中共同上调同源异型盒基因为NANOG基因，且同时出现在5张芯片中；共同下调的同源异型盒基因中，出现在7张芯片中的为PHTF2基因，出现在5张芯片中的分别为CRX、PITX1和OTEX。结论同源异型盒基因是细胞正常增殖和分化的关键基因，与肿瘤发生、发展密切相关。

英文摘要：

Objective To investigate the differently expressed Homeobex genes between lingual squmaons cell carcinoma and normal mucosa. Methods Seven paired specimens including lingual squmaous cell carcinoma and its surrounding normal tissue were obtained from 7 patients. Customized Oligo microarray which contains numerous probes of 232 human Homeobox genes was used to analyse the results. All datas were scanned by Agilent scanner and di.fferentiately expressed genes were sorted out. Results Homeobox gene NANOG was found up-regulated in 5 samples. PHTF2 was found down-regulated in 7 samples, and CRX, PITX1, OTEX was found down-regulated in 5 samples. Conclusion As the key gene to cellular proliferation and differentiation, Homeobox genes is closely releverant to the oncogenesis of lingual squmaous cell carcinoma.