中文摘要：

目的：研究高渗性海水（HS）和等渗性海水（IS）对变应性鼻炎（AR）小鼠鼻黏膜的影响，并初步探讨海水鼻腔盥洗治疗AR的机制。方法：将Der p1构建的BALB／c小鼠AR动物模型随机分为3组：HS组、IS组和空白对照组（BC组）。HS组和IS组造模完成后第1～14天分别给予希诺宁（NaCl2．3％）和必通（NaC10．9％）滴鼻，BC组造模完成后不予任何处理。阴性对照组不予任何处理，4组均在第14天末次给药后30min内计数小鼠喷嚏及挠鼻次数；并在末次给药24h后取各组小鼠鼻部组织固定，苏木精一伊红染色，通过透射电镜观察鼻黏膜微观结构。结果：AR小鼠经HS和IS滴鼻后，挠鼻及喷嚏次数较阴性对照组明显减少（P〈0．05）；HS组、IS组小鼠鼻黏膜组织中嗜酸粒细胞与BC组比较差异无统计学意义（P〉0．05）；HS组、IS组小鼠鼻黏膜纤毛柱状上皮细胞排列整齐，明显好于BC组，并且HS组小鼠鼻黏膜形态和微观结构较IS组更接近阴性对照组。结论：HS和IS鼻腔盥洗均可以促进损伤的鼻黏膜纤毛上皮修复，而且HS鼻腔盥洗促进损伤的鼻黏膜纤毛上皮修复作用好于IS。海水鼻腔盥洗治疗AR的作用机制可能是通过促进损伤的鼻黏膜纤毛上皮修复，从而减轻鼻部症状。

英文摘要：

Objective：To study the effect of hypertonic seawater and isotonic seawater for nasal mucosa of al- lergic rhinitis mice model, and explore the possible mechanism of nasal irrigation with seawater in treatment of al- lergic rhinitis. Method..We used Der pl to make allergic rhinitis model of BALB/c mice, and divided them into three groups randomly. Nasal irrigation with hypertonic seawater （HS） or isotonic seawater （IS） in the treatment group 1-14 days after modeling, and black control （BC） group was given no treatment after modeling. Normal control （NC） group was given no treatment, the number of rubs and sneezings in each group were counted in 30 rain after the last nasal irrigation. Mice were then killed 24 h after the last therapy. The noses of mice from each group were removed and fixed, then the slices were stained with hematoxylin and eosin, the others were observed by transmission electron microscope. Result： Mice with hypertonic seawater and isotonic seawater were significantly improved in rubs and sneezings compared to the black control group （P〈0.05）;The number of eosinophiles in mucosal tissues of HS group and IS group had no significant difference with that of the black control group （P〉 0.05） ~Ciliated columnar epithelium cells in mucosal tissues of HS group and IS group were arranged trimly, better than that in the black control group. Morphology and microstructure in nasal mucosat of HS group was closer to the normal group than in IS group. Conclusion：The injury of nasal mucosa ciliated epithelium was significantly im- proved by nasal irrigation with hypertonic seawater and isotonic seawater, and the former is better than the latter, the mechanism of nasal irrigation with seawater in treatment of allergic rhinitis may rely on repairing the injured nasal mucosa ciliated epithelium,thereby the symptoms of nasal was reduced.