用苯-二-[4-(十三氟正辛基)苯基]膦和二-(十三氟正辛基)重氮二羧酸酯作氟双相催化剂,在THF中由邻苯二甲酰亚胺和异丙醇合成N-异丙基邻苯二甲酰亚胺。反应条件为:邻苯二甲酰亚胺0.14mmol,n(胺):n(醇)=1.0:1.5,n(胺):n(催化剂)=1.0:1.5,室温反应3.0h,产率83.4%,纯度99.5%(GC分析)。
Using phenyl-bis- [ 4- ( tride eafluorooctyl) phenyl ] phosphane and bis- ( tride eafluorooctyl) diazo diearboxylate as fluorous biphasie catalyst, N-isopropyl phthalimide was synthesized from phthalimide and isopropanol in THF. Under the reaction conditions that phthalimide was 0. 14 mmol, the molar ratio of phthalimide to isopropanol was 1.0 : 1.5, the molar ratio of phthalimide to catalyst was 1.0 : 1.5, the yield was 83.4% and the purity reached 99.5% after reaction at room temperature for 3.0 h.