中文摘要：

肌球蛋白X（myosin X,Myo X）是一类尾部具有MyTH4（myosin tail homology 4,MyTH4）和FERM（band4.1/ezrin/radixin/moesin,FERM）结构域的非传统型肌球蛋白,广泛分布于脊椎动物细胞中.近几年的研究表明,Myo X尾部结构域能够与众多的信号分子相互作用,参与调节从丝状伪足形成到胞质分裂等多种细胞运动过程,但其具体的调控机制目前尚不完全清楚.Myo X作为一类连接细胞膜与细胞骨架的动力蛋白分子,它的研究越来越受到人们的关注,其功能的揭示将为进一步阐明细胞多种运动机制提供理论依据.

英文摘要：

Myosin X（Myo X） is an unconventional myosin with a tail of homology 4-band 4.1/ezrin/radixin/moesin（MyTH4-FERM） tail.It is ubiquitously expressed in various mammalian tissues.Recently,Myo X was found to interact with several molecules involved in signal transduction pathways that affected the cellular motility processes ranging from filopodial formation to cytokinesis.Myo X,as one of the MyTH-FERM myosins,is increasingly recognized as a key mediator of membrane-cytoskeleton interactions,yet the exact mechanism of its function was not fully understood.In this review,the literature on Myo X and cell motility are summarized.