中文摘要：

目的：探讨食管鳞状细胞癌（ESCC）组织中程序性细胞死亡1（PD-1）、CD45RO和OX40的表达状况及意义。方法：应用免疫组化SP法检测118例ESCC、39例癌旁不典型增生及39例正常食管组织中PD-1、CD45 RO和OX40的表达情况。结果：3种组织中PD-1、CD45 RO和OX40的阳性表达率差异有统计学意义（χ2＝32．923，24．171，33．008， P＜0．001）。 ESCC组织中3者的表达明显高于正常组织（P＜0．01）。 OX40的表达与ESCC患者的TNM分期、淋巴结转移有关（χ^2＝8．787，9．756，P＜0．05），PD-1、CD45RO的表达与ESCC患者临床病理指标无关（P＞0．05）。 ESCC组织中OX40与CD45RO的表达呈正关联（rP ＝0．351，P＜0．001）。结论：PD-1、CD45RO和OX40可能在ESCC恶变过程中发挥了重要作用。 OX40可能与ESCC的侵袭和转移有关。

英文摘要：

Aim：To study the expressions of PD-1,CD45RO and OX40 in esophageal squamous cell carcinoma （ES-CC） tissue.Methods：The expressions of PD-1,CD45RO and OX40 were detected by immunohistochemistry in 118 cases of ESCC,39 cases of adjacent atypical hyperplasia and 39 cases of normal esophageal tissue .Results：There were signifi-cant differences in the expressions of PD-1, CD45RO and OX40 among the 3 kinds of tissue （χ^2 =32.923,24.171 and 33.008, P〈0.001）.The expressions of PD-1, CD45 RO and OX40 in ESCC were significantly higher than those in nor-mal esophageal mucosa （P 〉0.01）.The expression of OX40 in ESCC tissue was significantly associated with TNM stage and lymph node metastasis（χ^2 =8.787,9.756, P〈0.05）.No correlation was found between the expression of PD-1 and CD45RO in ESCC （P〉0.05）.OX40 expression was positively associated with CD45RO expression in ESCC（rP =0.351, P〈0.001）.Conclusion：PD-1, CD45RO and OX40 protein may play key roles in the carcinogenesis of ESCC .Further-more, OX40 might directly influence invasiveness and metastasis of ESCC .