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Derivation of androgenetic embryonic stem cells from m-carboxycinnamic acid bishydroxamide (CB HA) treated androgenetic embryos
  • ISSN号:1007-7847
  • 期刊名称:《生命科学研究》
  • 时间:0
  • 分类:Q25[生物学—细胞生物学] TS218[轻工技术与工程—粮食、油脂及植物蛋白工程;轻工技术与工程—食品科学与工程]
  • 作者机构:[1]College of Life Sciences, Northeast Agricultural University of China, Harbin 150030, China, [2]State Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology, Chinese Academy of Sciences,Beijing 100101, China
  • 相关基金:This work was supported by the National Basic Research Program of China (2013CB967102) and the National Nat- ural Science Foundation of China (31201112). We thank Yangjie Lu from Institute of Zoology, Chinese Academy of Sciences, for her valuable comments on our manuscript writing.
中文摘要:

糖尿病 mellitus,在房间由胰岛素分泌物的损害新陈代谢描绘了,在全世界正在成为最流行的疾病之一。最近,包括胚胎的干细胞,房间代替基于各种各样的 pluripotent 干细胞的区别导致了 pluripotent 干细胞和 multipotent 干细胞,例如骨头髓间充质的干细胞,脂肪质导出干细胞和 gnotobiotic 猪的导出皮的干细胞,正在成为有希望的治疗学的策略。从与房间区别相关的胰腺的纸巾或另外的纸巾导出的房间也被用作房间来源。尽管有有希望的试验性的结果,然而,在糖尿病的房间治疗仍然面对某些障碍,例如房间,干细胞的功能的区别和可能的 tumorigenesis 的纯净,接着,它导致寻求新产生的工具,例如无生源的材料。在这评论,我们将在糖尿病 mellitus 总结房间治疗的当前的知识和未来前景。

英文摘要:

Diabetes mellitus, characterized by the impaired metabolism of insulin secretion in β cells, is becoming one of the most prevalent diseases around the world. Recently, cell replacement based on differentiation of various pluripotent stem cells, including embryonic stern cells, induced pluripo- tent stem cells and multipotent stem cells, such as bone mar- row mesenchymal stem cells, adipose-derived stem cells and gnotobiotic porcine skin-derived stem cells, is becoming a promising therapeutic strategy. Cells derived from pancreatic tissues or other tissues that are relevant to β cell differentiation have also been used as cell source. However, in spite of hopeful experimental results, cell therapy in diabetes still confronts certain obstacles, such as purity of cells, functional differentiation of stem cells and possible tumorigenesis, which, in turn, lead to the seeking of new-generation tools, such as xenogenetic materials. In this review, we will sum- marize the current knowledge and future prospects of cell therapy in diabetes mellitus.

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期刊信息
  • 《生命科学研究》
  • 北大核心期刊(2011版)
  • 主管单位:湖南师范大学
  • 主办单位:湖南师范大学
  • 主编:梁宋平
  • 地址:长沙湖南师范大学生命科学学院1号档127#
  • 邮编:410081
  • 邮箱:life@hunnu.edu.cn
  • 电话:0731-8872616
  • 国际标准刊号:ISSN:1007-7847
  • 国内统一刊号:ISSN:43-1266/Q
  • 邮发代号:42-172
  • 获奖情况:
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,美国化学文摘(网络版),美国剑桥科学文摘,英国动物学记录,中国中国科技核心期刊,中国北大核心期刊(2011版)
  • 被引量:5334