中文摘要：

线粒体转录终止因子（mitochondrial transcription termination factor,MTERF）蛋白家族广泛存在于多细胞动物与植物。目前在无脊椎动物中主要侧重海胆线粒体DNA结合蛋白（mitochondrial DNA binding protein,mtDBP）和果蝇线粒体转录终止因子（Drosophila mitochondrial transcription termination factor,D-MTERF）的研究。它们两者都在无脊椎动物线粒体转录终止过程中发挥作用,同时也参与调控线粒体DNA复制过程和转录起始过程。无脊椎动物MTERF蛋白的研究,对阐明MTERF蛋白家族各成员复杂多样的功能,以及理解线粒体转录终止的分子机制具有重要的意义。

英文摘要：

Mitochondrial transcription termination factors （MTERFs） are widely found in metazoans and plants. At present, the study focused on MTERF protein family includes two invertebrate mitochondrial transcription termination factors, sea urchin mtDBP and Drosophila D-MTERF. Both are involved in terminating transcription, and have also been implicated in transcription initiation and regulation of mtDNA replication. This multiplicity of functions appears to be a theme in the MTERF protein family, and the current understanding of these two invertebrate termination factors can provide insight into the complex and diverse regulatory roles of MTERF protein family members, as well as the mitochondrial transcription termination process.