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中文摘要：
一叶萩生物碱是从大戟科植物一叶萩,叶下珠属以及白饭树属中提取的一类化合物。它们中大部分呈现出广泛的生物活性,例如GABA受体拮抗活性,抗疟和抗菌活性。由于它的结构的特殊性,合成不同骨架的一叶萩生物碱对于有机化学和药物化学家来说是具有挑战性的工作。在本文中我们对几种一叶萩碱的全合成以及生物活性进行了概述。
英文摘要：
The Securinega alkaloids are a group of compounds isolated from the plants of Securinega,Phyllanthus and Flueggea genera belonging to the Euphorbiaceae family.Most of these compounds exhibit a wide range of biological activities,such as GAB A receptor antagonist,antimalarial and antibacterial activity.Due to the special structural features of Securinega alkaloids, the synthesis strategies for their different structural skeletons are challenging for organic and medicinal chemists.In the review, we will provide an overview of the total synthesis of several Securinega alkaloids and their biological activities.
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