中文摘要：

药代动力学的性别差异是临床上药物疗效的重要影响因素。引起药代动力学性别差异的比较重要的分子因素包括药物代谢酶和药物转运体等。CYP3A4是人体含量最丰富的酶，具有广泛的代谢底物。大部分体内、外研究表明CYP3A4底物的代谢具有明显的性别差异，女性体内的代谢快于男性。该文系统综述人肝脏CYP3A4酶介导的药物代谢性别差异的研究进展。

英文摘要：

Gender-related differences in drug pharmacokinetics have frequently been considered as potentially important determinants for the clinical effectiveness of drug therapy. Major molecular factors involved in drug disposition include drug-metabolising enzymes and drug transporters. Oxidative drug metabolism by cytochrome P450 （CYP） enzymes is a major pathway for drugelimination. CYP3A4, the major human drug-metabolizing CYP enzymes, has repeatedly been suggested higher metabolic activity in women than that in men, which sex-dependent secretory patterns of growth hormone that may be responsible for.