中文摘要：

人群跟踪调查表明,反式脂肪酸（trans fatty acids,TFA）增加冠心病危险及死亡率,可能主要通过影响血脂和炎症反应引起某些慢性疾病。实验在脂肪供能33%（目前中国居民膳食供能比）的情况下,通过90d的大鼠饲养实验探讨以TFA为主的脂肪摄入对大鼠体内脂质代谢的影响。结果表明：与基础饲料对比,以TFA为主的脂肪摄入显著升高大鼠血液甘油三酯（TG）含量,显著降低大鼠高密度脂蛋白胆固醇（HDL-C）含量,显著降低血浆肝素前脂蛋白脂酶（LPL）和肝脂酶（HL）的活力,显示TFA可能改变大鼠脂肪酸代谢,引起甘油三酯代谢异常;TFA同时显著降低大鼠血液血清总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）含量,且对C反应蛋白（CRP）没有影响,显著升高HDL-C/LDL-C,表明以TFA为主的脂肪摄入可能并不引起大鼠胆固醇代谢异常,这可能是由于除基础饲料外,植物油的摄入没有引入外源胆固醇,且大鼠本身缺乏胆固醇转移蛋白（CETP）。

英文摘要：

Epidemiological studies have demonstrated that trans-fatty acid （TFA） intake from diet increase the risk of some chronic diseases through blood lipid metabolism and inflammation pathway. Under the condition of oil added TFA with cholesterol-free （0% cholesterol） and 33% energy supplement from fat,the effect of TFA on lipid metabolism of rats was observed during 90 d feeding. The experimental diet with TFA significantly increased TG,lowered HDL-C,LPL and HL activity,suggesting that TFA could change fatty acid profile to induce the abnormity of TG metabolism. Meanwhile,TFA significantly depressed TC and LDL-C and improved HDL-C/LDL-C ratio,but did not exhibit effect on C-reactive protein （CRP） due to having no effect on the abnormity of cholesterol metabolism.