中文摘要：

目的观察HIFU损伤30只活体兔肝组织的MRI监控图像，探讨MRI图像变化及与实际损伤的关系。 方法采用不同剂量HIFU辐照活体兔肝组织，于术后即刻进行T1WI、T2WI、PDWI、增强T1WI扫描。观察并测量MRI显示损伤灶与实际损伤灶面积，同时取损伤组织HE染色病理检查。 结果所有30只损伤灶中，30只于T1WI中为边界清晰的高信号，与实际黄白色损伤面积比较无统计学差异（P〉0．05）。损伤灶于T2WI（18只）和PDWI（3只）中为稍低信号。30只损伤灶于增强T1WI中无强化，其中17例无强化区面积大于实际损伤面积。 结论MRI能有效监控及评价HIFU辐照活体兔肝组织的效果。

英文摘要：

Objective To observe the MRI images of rabbit liver damaged by MRI-guided HIFU and to study the relationship between images and the practical necrosis. Methods 30 rabbit liver tissues in vivo were exposed to MRI-guided HIFU with different intensity. Instantly after that, T1WI, T2WI, PDWI, and enhanced -T1WI were performed. Then observe and measure the lesions on MRI and gross anatomy Meanwhile the lesions were got to be HE stained. Results There were 30 lesions in all. 30 lesions on T1WI were hyperintense,and the lesion area on T1WI highly correlated with practical necrosis （P〉0. 05）. The lesions on T2WI（18） and PDWI（3） were slightly hypointense. Lesions on enhanced-T1WI were all without enhanced,and the area of 17 no-enhancement lesions were greater than that of practical necrosis. Otherwith the pathological examination showed the lesions were all coagulation necrosis. Conclusions MRI was useful to monitor the HIFU treatment and to evaluate the curative effect accurately.