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胰岛素抵抗与代谢综合征及其组分的相关性分析
  • ISSN号:1007-9572
  • 期刊名称:《中国全科医学》
  • 时间:0
  • 分类:R587.1[医药卫生—内分泌;医药卫生—临床医学;医药卫生—内科学]
  • 作者机构:[1]延边大学医学院预防医学教研部,吉林延吉133002
  • 相关基金:国家自然科学基金项目(30260098,30860244);吉林省教育厅基金项目(2008-2).
中文摘要:

[目的]分析延边农村地区朝鲜族和汉族居民胰岛素抵抗(IR)与代谢综合征(MS)及其组分的相关性.[方法]采用整群抽样和简单随机抽取的方法抽取7836名延边朝鲜族自治州农村地区常住朝鲜族和汉族进行现况调查.采用家访的方法收集研究对象的一般情况、心脑血管疾病的既往史及家族史等相关信息.通过健康体检准确测量身高、体质量、腰围、臀围、血压等体格指标.取清晨空腹(禁食12h)静脉血,测量胰岛素、血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL—C)、血糖等生物化学指标.[结果]不同性别汉族IR组的整体型肥胖、腹型肥胖、高TG血症、低HDL—C血症、高血压、高血糖及MS患病风险高于非IR组,其差异均有统计学意义(P〈0.01);不同性别朝鲜族IR组的上述诸多代谢异常(低HDL.C血症除外)的患病风险高于非IR组,其差异均有统计学意义(P〈0.01).偏相关分析结果显示,IR与整体型肥胖、腹型肥胖、高TG血症、低HDL.C血症、高血压、高血糖及MS均明显呈正相关,相关系数分别为0.161,0.137,0.125,0.120,0.074,0.422,0.196(P〈0.01).[结论]延边农村地区不同民族IR组的整体型肥胖、腹型肥胖、高TG血症、低HDL—C血症、高血压、高血糖及MS患病风险高于非IR组.

英文摘要:

OBJECTIVE To analyze the relationship between insulin resistance (IR) and metabolic syndrome (MS) and its components in Korean-Chinese and Han nationality residents in countryside of Yanbian. METHODS 7 836 cases of permanent residents in countryside of Yanbian were selected by chester sampling and simple random sampling to perform the inventory survey. The relevant data for this study were collected by family visit and health physical examination, including the general information, past history and family history of cardiovascular and cerebrovascular diseases, etc, and anthropometric indices (height, weight, waist and hip circumference) and blood pressure. In addition, the biochemistry indexes of insulin, serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and blood glucose were measured from early morning venous blood after 12h fasting. RESULTS The risks of suffering from the overall obesity, central obesity, hypertriglyceridemia, low HDL-C, hypertension,hyperglycemia and MS in Korean-Chinese (except low HDL-C) and Han nationality were significantly higher in IR group than in non-IR group (P〈0.01), and the partial correlate analysis showed that there was a significant positive correlation between IR and overall obesity, central obesity, hypertriglyceridemia, low HDL-C, hypertension, hyperglycemia and MS, the partial correlate coefficient was 0. 161, 0. 137, 0. 125, 0. 120, 0. 074, 0. 422 and 0. 196 (P〈0.01). CONCLUSION The risks of suffering from the overall obesity, central obesity, hypertriglyceridemia, low HDL-C, hypertension, hyperglycemia and MS in different nationalities of countryside of Yanbian are significantly higher in IR group than in non-IR group.

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期刊信息
  • 《中国全科医学》
  • 北大核心期刊(2011版)
  • 主管单位:中华人民共和国国家卫生和计划生育委员会
  • 主办单位:中国医院协会 中国全科医学杂志社
  • 主编:韩建军
  • 地址:北京市西城区广义街5号广益大厦A座907
  • 邮编:100053
  • 邮箱:zgqkyx@chinagp.net.cn
  • 电话:010-63052088 83525550
  • 国际标准刊号:ISSN:1007-9572
  • 国内统一刊号:ISSN:13-1222/R
  • 邮发代号:80-258
  • 获奖情况:
  • 获2000-2001年度河北省优秀期刊
  • 国内外数据库收录:
  • 美国化学文摘(网络版),波兰哥白尼索引,中国中国科技核心期刊,中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版)
  • 被引量:91748