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中文摘要：
申请人主要研究了碳氢键选择性直接官能团化反应一是过渡金属催化，发展了铱催化的自由氨基协助的烯烃碳氢键活化策略，提出烯丙基烯基化概念，实现了烯丙基烯基化/不对称胺化串联反应；二是布朗斯特酸催化，发展了布朗斯特酸催化的不对称傅克烷基化反应，提出了串联催化的概念，实现了烯烃复分解/手性布朗斯特酸催化串联反应；三是氮杂环卡宾催化，合成了樟脑衍生的新型手性氮杂环卡宾催化剂，发展了全新的扩环反应模式。回国独立工作以来已在JACS (3)、Angew Chem (3)等杂志上发表论文39篇。这些工作将惰性碳氢键活化及不对称合成这两个当前有机化学中的前沿热点领域结合起来，对于有机化学的基础理论研究有重要的贡献。这类反应具有原料易得、原子经济等优点，有望为绿色精细化工提供技术支撑。在上述研究工作基础上，进一步工作拟调节金属、配体和导向基团来实现普通芳烃和烷烃的碳氢键直接官能团化反应，并实现对映选择性控制。
英文摘要：
C-H functionalization；ligand；dearomatization；asymmetric catalysis；allylic substitution
结论摘要：
本项目研究了碳氢键选择性直接官能团化及不对称去芳构化反应1) 实现了自由芳胺为导向基团铱催化碳氢键活化，该导向基团被同行广泛使用；2) 在铱催化的不对称烯丙基取代反应中，首次发现N芳基配体中C(sp2)-H活化新机制，合成的新配体更为简单、底物适用范围广、对映选择性高，目前已经实现了商品化，并被同行应用；3) 利用金属催化的不对称碳氢键活化反应实现二茂铁平面手性和轴手性骨架的构建，条件温和，便于大量生产，实用性强；4) 提出了催化不对称去芳构化(CADA)反应概念，实现了一系列芳香化合物包括吲哚、吡咯、苯酚、萘酚、吡啶、吡嗪高效不对称去芳构化反应，为含有季碳中心的螺环化合物提供了便捷的合成方法，利用新反应方法，实现了多个天然产物的简洁全合成；5) 首次发现螺假吲哚环化合物在酸催化下发生立体专一性的迁移反应，纠正了文献错误，为芳香化合物分子内烷基化反应提供机理指导。在此期间共发表论文88篇，影响因子>5的56篇。
成果综合统计
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期刊论文
Desymmetrization of cyclohexadienones via D-camphor-derived triazolium salt catalyzed intramolecular
Enantioselective synthesis of fluorene derivatives by chiral N-triflyl phosphoramide catalyzed doubl
Highly Regio- and Enantioselective Synthesis of N-Substituted 2-pyridones via Ir-Catalyzed Intermole
Chiral Phosphoric Acid-Catalyzed Asymmetric Cascade Reaction of C3 Substituted Indoles and Methyl Vi
Organocatalyzed Enantioselective Formal [4 + 2] Cycloaddition of 2,3-Disubstituted Indole and Methyl
Desymmetrization of Cyclohexadienones via Intramolecular Stetter Reaction to Construct Tricyclic Car
Construction of Spiro-tetrahydroquinolines via Intramolecular Dearomatization of Quinolines: Free of
DPEN-derived Triazolium Salts Catalyzed Annulation Reactions of？,β-Unsaturated Aldehydes with 1,3-Di
Highly Enantioselective Synthesisof Tetrahydrocarbolines via Iridium-Catalyzed Intramolecular Friede
Desymmetrization of cyclohexadienones via cinchonine derived thiourea-catalyzed enantioselective aza
Enantioselective Synthesis of Benzofurans and Benzoxazines via Olefin Cross-Metathesis/Intramolecula
Enantioselective Synthesis of Planar Chiral Ferrocenes via Pd(0)-Catalyzed Intramolecular Direct C-H
Enantioselective Construction of Pyrroloindolines via Chiral Phosphoric Acid Catalyzed Cascade Micha
An olefin isomerization/asymmetric Pictet-Spengler cascade via sequential catalysis of ruthenium alk
Palladium-Catalyzed Intermolecular Allylic Dearomatization Reaction of alpha-Substituted beta-Naphth
Regio-and Enantioselective Synthesis of N-Allylindoles by Iridium-Catalyzed Allylic Amination/Transi
Highly Regio- and Enantioselective Synthesis of Polysubstituted 2H-Pyrroles via Pd-Catalyzed Intermo
Ruthenium-Catalyzed Intramolecular Allylic Dearomatization/Migration Reaction of Indoles and Pyrrole
Synthesis of 1- bis(trifluoromethyl)phosphine-1’-oxazoline ferrocene ligands and their application i
Pd(II)-Catalyzed Intermolecular Direct C-H Bond Iodination: An Efficient Approach towards the Synthe
Pd(0)-Catalyzed Alkenylation and Allylic Dearomatization Reactions between Nucleophile Bearing Indol
Asymmetric Synthesis of Tetrahydro-beta-carbolines via Chiral Phosphoric Acid Catalyzed Transfer Hyd
A Combined Theoretical and Experimental Investigation into the Highly Stereoselective Migration of S
Enantioselective Chlorocyclization of Indole Derived Benzamides for the Synthesis of Spiro-indolines
Palladium-Catalyzed Intermolecular Asymmetric AllylicDearomatization Reaction of Naphthol Derivative
Enantioselective synthesis of planar chiral ferrocenes via palladium-catalyzed annulation with diary
Synthesis of (1R, 2R)-DPEN-Derived Triazolium Salts and Their Application in Asymmetric Intramolecul
Iridium-Catalyzed Allylic Vinylation and Asymmetric Allylic Amination Reactions with o-Aminostyrenes
One-Pot Synthesis of Pyrrolo[1,2-a]indoles by Chiral N-Triflyl Phosphoramide Catalyzed Friedel-Craft
N-Alkylation of Indole via Ring-Closing Metathesis/Isomerization/Mannich Cascade under Ruthenium/Chi
Intramolecular Alkene Electrophilic Bromination Initiated ipso-Bromocyclization for the Synthesis of
Enantioselective Synthesis of Tetrahydroisoquinolines via Iridium-Catalyzed Intramolecular Friedel&a
Enantioselective synthesis of 2,5-dihydrobenzo[b]azepine derivatives via iridium-catalyzed asymmetri
Asymmetric dearomatization of pyrroles via Ir-catalyzed allylic substitution reaction: enantioselect
Highly Regioselective Allylic Substitution Reactions Catalyzed by an Air-Stable (pi-Allyl)iridium Co
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