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全基因组范围挖掘疾病相关基因的交互模式
  • 项目名称：全基因组范围挖掘疾病相关基因的交互模式
  • 项目类别：重点项目
  • 批准号：30730057
  • 申请代码：C06
  • 项目来源：国家自然科学基金
  • 研究期限：2008-01-01-2011-12-31
  • 项目负责人：JurgOtt
  • 负责人职称：教授
  • 依托单位：中国科学院心理研究所
  • 批准年度：2007
中文摘要：

本课题旨在开发新的遗传统计学方法，用于寻找与常见遗传性状相关的多个基因及交互。常见遗传疾病对公众健康存在强烈的影响。这些疾病更加趋向于是由多个基因共同作用导致的。传统的遗传统计方法如连锁分析和关联分析主要用于发现单个致病基因。这里，我们将研究一种新的关联分析方法通过综合分析不同基因上的SNP发现位于基因组不同区域与疾病相关的突变多态组合。寻找这些与疾病相关联的多态组合是一个很难的统计计算任务，因为我们需要找遍10万个或更多的SNP位点的组合。这里需要结合计算机领域的技术，如数据库技术，模式识别技术等。当前已有的频繁项集挖掘（Frequent Itemset Mining）方法是解决该类组合爆炸问题的主要方法。但这类方法解决的组合问题与我们的组合问题尚有本质区别。我们将研究这类算法的本质并结合生物学背景，开发新方法。研究成果将做成免费软件，用于确定常见遗传性状如糖尿病，心脏病等多基因疾病。

中文主题词： 方法；模型；病例-对照关联分析；位点
结论摘要：

英文主题词approach; model; case-control association studies; locus

成果综合统计
成果类型
数量
  • 期刊论文
  • 会议论文
  • 专利
  • 获奖
  • 著作
  • 39
  • 6
  • 0
  • 0
  • 0
期刊论文
CpG Island Methylator Phenotype Associates with Low-Degree Chromosomal Abnormalities in Colorectal C
CFH and LOC387715/ARMS2 genotypes and treatment with antioxidants and zinc for age-related macular d
Genetic susceptibility to heroin addiction: a candidate gene association study
Genotype patterns that contribute to increased risk for or protection from developing heroin addicti
Rhesus monkeys and humans share common susceptibility genes for age-related macular disease
TPH2 and TPH1: Association of variants and interactions with heroin addiction
Writings on Genetic Linkage in the Annals
Systematic Removal of Outliers to Reduce Heterogeneity in Case-Control Association Studies
Genetic predisposition for femoral neck stress fractures in military conscripts
Associations of Six Single Nucleotide Polymorphisms in Obesity-Related Genes With BMI and Risk of Ob
Genome-Wide Conditional Search for Epistatic Disease-Predisposing Variants in Human Association Stud
Ethnic diversity of DNA methylation in the OPRM1 promoter region in lymphocytes of heroin addicts
Evidence for association of two variants of the nociceptin/orphanin FQ receptor gene OPRL1 with vuln
Progression of Geographic Atrophy and Genotype in Age-Related Macular Degeneration
Association of polymorphisms of the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH
Joint Identification of Multiple Genetic Variants via Elastic-Net Variable Selection in a Genome-Wid
Pilot Study on Schizophrenia in Sardinia
Genome-wide examination of genetic variants associated with response to platinum-based chemotherapy
Genome-wide association study identifies genes that may contribute to risk for developing heroin add
Adjusting for HLA-DRb1 in a genome-wide association analysis of rheumatoid arthritis and related bio
Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular dege
MHC fine mapping of human type 1 diabetes using the T1DGC data
Genome-Wide Autozygosity Mapping in Human Populations
Increased OPRM1 DNA Methylation in Lymphocytes of Methadone-Maintained Former Heroin Addicts
Testing Association with Interactions by Partitioning Chi-Squares
Scan statistics in genome-wide scan for complex trait loci
A Functional Haplotype Implicated in Vulnerability to Develop Cocaine Dependence is Associated with
William Allan Award Address: On the Role and Soul of a Statistical Geneticist
Family-based designs for genome-wide association studies
Multilocus association mapping using generalized ridge logistic regression
Multiple phenotypes in genome-wide genetic mapping studies
Association of polymorphisms in the melanocortin receptor type 2 (MC2R, ACTH receptor) gene with her
Collapsing SNP genotypes in case-control genome-wide association studies increases the type I error
会议论文
P-value distribution in case-control association studies
Variants of mu opioid receptor influence hiv viral load change in individuals before initiating haar
Variants of kappa opioid receptor influence viral load of hiv positive females on haart
Testing the genetic control parameter
Detecting gene-gene interactions using support vector machines with l1 penalty
Multilocus association analysis under polygenic models
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JurgOtt的项目