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朊病毒（prion）抗氧化与促氧化作用的分子机理
  • 项目名称：朊病毒（prion）抗氧化与促氧化作用的分子机理
  • 项目类别：青年科学基金项目
  • 批准号：30100035
  • 申请代码：C050605
  • 项目来源：国家自然科学基金
  • 研究期限：2002-01-01-2004-12-01
  • 项目负责人：张红雨
  • 负责人职称：教授
  • 依托单位：山东师范大学
  • 批准年度：2001
中文摘要：

综合不同学科的实验与理论计算方法，明确prion与二价铜离子（Cu2）的络合模式，确定私鹗袈绾衔锴宄跻趵胱幼杂苫乃俾食Ｊ捌湎虼傺趸磷姆肿踊疲唤驼庵肿痰慕峁垢矗⒀芯恐醒趸逃雙rion散发性的关系；最后探讨天然抗氧化剂对prion-Cu2+络合物促氧化活性的抑制作用，为阐明prion的致病机理和寻找有效治疗药锏於ɑ

中文主题词： 朊病毒、错误折叠、金属离子、自由基、抗氧化剂
结论摘要：

英文主题词prion、misfolding、metal ions、free radical、antioxidants

成果综合统计
成果类型
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  • 期刊论文
  • 会议论文
  • 专利
  • 获奖
  • 著作
  • 4
  • 0
  • 0
  • 0
  • 18
期刊论文
Electronic effects on O-H proton dissociation energies of phenolic cation radicals. A DFT study.
Successful application of TD-DFT in transient absorption spectra assignment
水杨酸甲酯清除羟基自由基活性的研究
Substituent Effect on Proton Affinity of Imidazole in Cu,Zn-Superoxide Dismutase
著作
Theoretical elucidation of structure-activity relationship for coumarins to scavenge peroxyl radical.
On the effectiveness of EPR radical equilibration technique in estimating O-H bond dissociation enthalpies of catechols and other complex polyphenols.
Unexpected role of 5-OH in DPPH radical-scavenging activity of 4-thiaflavans. Revealed by theoretical calculations.
Theoretical elucidation of nitrogen dioxide radical-scavenging activity difference of hydroxycinnamic acid derivatives.
DFT calculations indicate that 1,4-dihydropyridine is a promising lead antioxidant.
A new strategy to combat Alzheimer’s disease. Combining radical-scavenging potential with metal-protein-attenuating ability in one molecule
Radical scavenging potential of phenolic compounds encountered in O. Europaea products as indicated by calculation of bond dissociation enthalpy and ionization potential values
Theoretical investigation on radical-coupling reactivity of indolinonic aminoxyls
Theoretical elucidation on structure-antioxidant activity relationships for indolinonic hydroxylamines
Are allylic hydrogens in catechins more abstractable than catecholic hydrogens.
1,4-Pyrone effects on O-H bond dissociation energies of catechols in flavonoids: A density functional theory study
脉冲辐解研究3,4－亚甲二氧基苯甲醛的亲电性
On the O-H bond dissociation enthalpy of catechol
Why B-ring is the active center for genistein to scavenge peroxyl radical. A DFT study.
A theoretical investigation on DPPH radical-scavenging mechanism of edaravone.
Substituent effects on O-H bond dissociation enthalpies and ionization potentials of catechols: a DFT study and its implications in rational design of phenolic antioxidants and elucidation of structur
S-H proton dissociation enthalpies of thiophenolic cation radicals. A DFT study
A DFT study on intramolecular hydrogen bonds in substituted catechols and their radicals
张红雨的项目
正常牛胰岛素抑制剂与突变热力学稳定性差异的研究
从传统中药组方中用NMR方法筛选抑制淀粉样蛋白形成活性分子