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中文摘要：
心律失常是心脏激动的起源和或传导异常，它是临床上最常见的一大类重大心血管疾病。心律失常尤其是心脏颤动的发生机制始终是心脏病学和相关生命科学研究领域的焦点，也是医学科学的重大难题。本项目旨在探索心律失常的发生机制，主要研究方向包括（1）、细胞内物流系统与心律失常的关系；（2）、心律失常的发育生物学调控；（3）、心律失常的表观遗传学调控。在“教育部创新团队”计划项目资助下，我们群体在心脏颤动研究领域取得了重要的发现，本项目是过去工作的延续和拓展。经过十多年的凝练，我们实验室已经汇聚了一批海内外精英，他们带着共同的研究兴趣，优势互补，强强联合，携手开展心律失常发生机制研究。我们的奋斗目标是在心律失常机制研究领域取得重要突破，培养和造就若干高水平的学者乃至战略科学家，建立一支国际水准的心律失常研究团队和研究基地，提升中国在心血管研究领域的国际竞争力和地位。
结论摘要：
英文主题词Arrhythmia；Electrical physiology；Molecular biology；Cell biology；Developmental biology
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陈义汉
NSFC国家创新研究群体基金项目、国家863计划项目、国家973计划项目、国家杰出青年科学基金项目、教育部创新团队计划项目、NSFC国际重大合作项目、NSFC重点项目、NSFC面上项目等。
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