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负性共刺激分子"B7-H4" 在脑胶质瘤干细胞免疫逃逸中的机理研究
  • 项目名称：负性共刺激分子"B7-H4" 在脑胶质瘤干细胞免疫逃逸中的机理研究
  • 项目类别：国家杰出青年科学基金
  • 批准号：81025013
  • 申请代码：H1618
  • 项目来源：国家自然科学基金
  • 研究期限：2011-01-01-2014-12-31
  • 项目负责人：毛颖
  • 负责人职称：教授
  • 依托单位：复旦大学
  • 批准年度：2010
中文摘要：

申请者长期从事脑肿瘤和脑血管病基础和临床研究。近年来主要学术成绩1）发现脑胶质瘤恶性程度与肿瘤干细胞样细胞增殖力有关，肿瘤复发与肿瘤细胞免疫逃逸有关。2)实现手术中实时脑功能区定位，提高病灶切除准确性,延长患者生存率。3）创建脑血流重建技术治疗复杂脑动脉瘤，使部分难治动脉瘤得到治愈。曾主持完成国家科技支撑计划（十一五攻关）1项、国家自然科学基金2项、上海市科委重点项目1项。作为第二完成人,获得国家科技进步二等奖1次，上海市科技进步一等奖2次，教育部科技进步一等奖和二等奖各1次，中华医学科技一等奖1次。获"卫生部有突出贡献中青年专家"和"上海市十大青年科技英才"称号。共发表论文132篇，其中SCI 41篇。近五年发表论文70篇，SCI收录31篇，其中以第一作者和通讯作者发表SCI收录论文10篇。

中文主题词： 胶质瘤；肿瘤干细胞；B7H4；B7H3；
英文摘要：

glioma；tumor stem cell；B7H4；B7H3；

英文主题词： glioma；tumor stem cell；B7H4；B7H3；
结论摘要：

经过4年努力，我们按原计划围绕B7家族和肿瘤干细胞（TSC）展开工作，在研究中对该课题有了全新的认识。首先我们对TSC的机制进行解析，发现了调控TSC分化的表观遗传学“开关”；另外与设想一样，我们证实B7家族蛋白在胶质瘤TSC中高表达并具有重要的临床意义，揭示了B7H4介导肿瘤微环境中TSC与小胶质细胞的“对话”，从而促进胶质瘤的免疫逃逸；同时与设想不同的是，B7H3具有调节分化的新功能，且通过TGF-β通路发挥作用。我们顺利完成研究任务，阐明了胶质瘤恶性进展的潜在机制，也为胶质瘤的免疫治疗提供了新思路。

成果综合统计
成果类型
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  • 期刊论文
  • 会议论文
  • 专利
  • 获奖
  • 著作
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期刊论文
Differential proliferative index of cancer stem-like cells in primary and recurrent medulloblastoma
Clinicopathological Analysis of Rhabdoid Meningiomas: Report of 12 Cases and a Systematic Review of
Histopathological classification and location of consecutively operated meningiomas at a single inst
B7-H3 and B7-H1 expression in cerebral spinal fluid and tumor tissue correlates with the malign
Intraoperative ultrasound assistance in resection of intracranial meningiomas.
Sensorimotor cortical changes assessed with resting-state fMRI following total brachial plexus root
The rs522616 polymorphism in the matrix metalloproteinase-3 (MMP-3) gene is associated with sporadic
Genetic variants in SLC7A7 are associated with risk of glioma in a Chinese population.
Current status of cerebral glioma surgery in China
Chordoid meningioma: a retrospective study of 17 cases at a single institution
Central nervous system tumors: a single center pathology review of 34,140 cases over 60 years.
Tracking induced pluripotent stem cells-derived neural stem cells in the central nervous system of r
Preliminary Experience of 256-Row Multidetector Computed Tomographic Angiography for Detecting Cereb
Clinicopathological analysis of metaplastic meningioma: report of 15 cases in Huashan Hospital.
Mouse glioma immunotherapy mediated by A2B5+ GL261 cell lysate-pulsed dendritic cells.
Consensuses and Controversies on Pineal Tumor Surgery
miR-21 in the Extracellular Vesicles (EVs) of Cerebrospinal Fluid (CSF): A Platform for Glioblastoma
Epigenetic suppression of EGFR signaling in G-CIMP+ glioblastomas.
Comments on Instrumentation in Neurosurgery
A novel CCM1 gene mutation causes cerebral cavernous malformation in a Chinese family
Surgical strategies for petroclival meningioma in 57 patients
MiR-383 is Downregulated in Medulloblastoma and Targets Peroxiredoxin 3 (PRDX3)
Olig2-positive cells in glioneuronal tumors show both glial and neuronal characters: The implication
Secretory meningiomas: clinical, radiological and pathological findings in 70 consecutive cases at o
Hemangioblastomas might derive from neoplastic transformation of neural stem cells/progenitors in th
The CD133+ tumor stem-like cell-associated antigen may elicit highly intense immune responses agains
Anterior Clinoidectomy in Skull Base Technique
CTLA4 A49G Polymorphism Shows Significant Association With Glioma Risk in a Chinese Population
The Value of Teleradiology in Neurosurgery
Huashan Hospital Affiliated to Fudan University: Spanning a Century of History
Treatment Strategies for Complex Internal Carotid Artery (ICA) Aneurysms: Direct ICA Sacrifice or Co
Prognostic prediction of patients with poor-grade aneurysmal subarachnoid hemorrhage and additional
MIR-137 Suppresses Growth and Invasion, is Downregulated in Oligodendroglial Tumors and Targets CSE1
Lymphoplasmacyte-rich meningioma: our experience with 19 cases and a systematic literature review
Papillary meningioma: clinical and histopathological observations
Intelligence deficits in chinese patients with brain tumor: the impact of tumor resection.
A unique case of Chinese language and music dissociation with tumor located in Broca's area: mu
Intensive management and prognosis of 127 cases with traumatic bilateral frontal contusions.
Evidence of brain tumor stem progenitor-like cells with low proliferative capacity in human ben
Identification of CD105 (endoglin)-positive stem-like cells in rhabdoid meningioma
Liangfu Zhou: Clinical Neurosurgeon, Academician, Teacher, and Friend
Emotion and cognitive function assessment of patients with central neurocytoma resection through tra
U87MG glioma cells overexpressing IL-17 acclerate early-stage growth and cause a higher level of CD3
High-mobility group box 2 is associated with prognosis of glioblastoma by promoting cell viability,
Complex middle cerebral artery aneurysms: a new classification based on the angioarchitecture and su
一种从新鲜脑胶质瘤标本中分离小胶质细胞的改良方法
<span style="font-size: 10.5pt; font-family: '宋体'; mso-spacerun: 'yes'&q
Bypass or Not? Adjustment of Surgical Strategies According to Motor Evoked Potential Changes in Larg
Combined Supratentorial and Infratentorial Approaches for Removal of Petroclival Meningiomas
Awake language mapping and 3-Tesla intraoperative MRI-guided volumetric resection for gliomas in lan
B7-H4 expression is elevated in human U251 glioma stem-like cells and is inducible in monocytes cult
Emotion and cognitive function assessment of patients with central neurocytoma resection through transcortical frontal approach： a 5-year postoperative follow-up study
脑干胶质瘤的现状及展望
精准神经外科：从宏观到微观
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　负性共刺激分子在复发胶质瘤中的作用机制研究
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