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中文摘要：
项目致力于精细化工领域染料分子结构与功能创新的研究，集中在新型生物医疗诊断用染料和数码记录用染料。项目提出通过调控光诱导激发态染料分子内电子转移（PET）、电荷转移（ICT）来提升染料的功能。 1.研究新的半导体红色激光器可激发的菁染料在血液细胞分析中的应用。这类ICT染料具有特有的大Stokes位移，通过染料对血细胞内RNA、DNA的特异性染色和半导体激光荧光检测，实现不成熟网织红细胞、有核红细胞、异常细胞及（五分类）白细胞的分类计数，由此形成新的具有自主知识产权的血液细胞分析技术。 2．调节荧光团和质子化的PET金属离子配体的HOMO能，从根本上消除质子（pH4-9）对PET荧光探针的干扰，使锌、汞、镉等过渡金属离子PET荧光探针具有实用性。 3．为了提高数码记录用染料的耐晒和耐臭氧性能，提出在染料分子内引入非共轭的电子受体，通过分子内电子转移（反PET）来淬灭染料激发态，抑制单线态氧的形成，使得黄、红、蓝、黑四原色染料的耐日晒耐臭氧性能从4-5级提高至7级以上。
结论摘要：
英文主题词fine chemicals; dyes; fluorescent dyes; fluorescent probes; chemosensors
成果综合统计
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期刊论文
A New Fluorescent Chemodosimeter for Hg(2+) : Selectivity, Sensitivity, and Resistance to Cys and GS
Optimized Conditions of Protein Prestained with Reactive Dye in Native Polyacrylamide Gel Electropho
A Hg2+-selective chemodosimeter based on desulfurization of coumarin thiosemicarbazide in aqueous me
Novel Water-soluble Asymmetric Cy5 Dyes: Synthesis, Photo-stabilities and Fluorescent Labeling Prote
Carboxyl BODIPY dyes from bicarboxylic anhydrides: One-pot preparation, spectral properties, photost
A new fluorescent sensor selective for Pb(2+) in water capable of two-photon-induced fluorescence me
Intra- and intermolecular interaction ECL study of novel ruthenium tris-bipyridyl complexes with dif
A new fluorescent sensor selective for Pb2+ in water capable of two-photon-induced fluorescence meas
A fluorescent chemodosimeter specific for cysteine: effective discrimination of cysteine from homocy
Redox-induced partner radical formation and its dynamic balance with radical dimer in cucurbit[8]uri
The Spectral Properties of Cy5 with Aldehyde Group Substituted at Meso-position of the Polymethine C
An effective minor groove binder as a red fluorescent marker for live-cell DNA imaging and quantific
A highly selective and sensitive two-photon chemosensor for silver ion derived from 3,9-dithia-6-aza
Selenium-bridged diiron hexacarbonyl complexes as biomimetic models for the active site of Fe-Fe hyd
Efficient enhancement of DNA cleavage activity by introducing guanidinium groups into diiron(III) co
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