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针对分子靶点的抗肿瘤药物发现及其机理研究
  • 项目名称：针对分子靶点的抗肿瘤药物发现及其机理研究
  • 项目类别：创新研究群体科学基金
  • 批准号：81021062
  • 申请代码：H3105
  • 项目来源：国家自然科学基金
  • 研究期限：2011-01-01-2013-12-31
  • 项目负责人：丁健
  • 负责人职称：研究员
  • 依托单位：中国科学院上海药物研究所
  • 批准年度：2010
中文摘要：

中文主题词抗肿瘤药物；分子靶向；机制研究；新药发现；

中文主题词：
英文摘要：

anti tumor drugs；molecularly - targeted；mechnistic study；drug discovery；

英文主题词： anti tumor drugs；molecularly - targeted；mechnistic study；drug discovery；
成果综合统计
成果类型
数量
  • 期刊论文
  • 会议论文
  • 专利
  • 获奖
  • 著作
  • 65
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期刊论文
Discovery and bioactivity of 4-(2-arylpyrido[3 ';,2 ';:3,4]pyrrolo[1,2-f][1,2,4]-triazin-4-yl) morph
Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: Synthesis and SAR study as tyrosine kina
Serratustones A and B Representing a New Dimerization Pattern of Two Types of Sesquiterpenoids from
Cytotoxic Diterpenoids from Sapium insigne
Inhibition of Chemokine (CXC Motif) Ligand 12/Chemokine (CXC Motif) Receptor 4 Axis (CXCL12/CXCR4)-m
D11, a novel glycosylated diphyllin derivative, exhibits potent anticancer activity by targeting top
Design of Cell-Permeable Stapled Peptides as HIV-1 Integrase Inhibitors
Characterization of a novel curcumin analog P1 as potent inhibitor of the NF-kappa B signaling pathw
Chukrasones A and B: Potential Kv1.2 Potassium Channel Blockers with New Skeletons from Chukrasia ta
Morusalbanol A, a neuro-protective Diels-Alder adduct with an unprecedented architecture from Morus
Extensive Crosstalk between O-GlcNAcylation and Phosphorylation Regulates Akt Signaling
Inhibition of tumor cell growth, proliferation and migration by X-387, a novel active-site inhibitor
PH006, a novel and selective Src kinase inhibitor, suppresses human breast cancer growth and metasta
Marine-Derived Angiogenesis Inhibitors for Cancer Therapy
Sysmatic combination screening reveals synergism between rapamycin and sunitinib against human lung
Organic carbonate from natural sources
Synthesis and revision of stereochemistry of rubescensin S
Design, Synthesis, and Biological Evaluation of a Series of Benzo[de][1,7]naphthyridin-7(8H)-ones Be
Daphnane-Type Diterpenoids from Trigonostemon howii
Design, synthesis and biological evaluation of substituted 11H-benzo[a] carbazole-5-carboxamides as
Potent HGF/c-Met Axis Inhibitors from Eucalyptus globulus: the Coupling of Phloroglucinol and Sesqui
Total Synthesis of Lathyranoic Acid A
Constituents of Trigonostemon heterophyllus
Ivorenolide A, an Unprecedented Immunosuppressive Macrolide from Khaya ivorensis: Structural Elucida
Cytotoxic sesquiterpenoids from Sarcandra glabra
Limonoids from the stems of Toona ciliata var. henryi (Meliaceae)
Synthesis and antitumor activity of 10-arylcamptothecin derivatives
Synthesis of 1,7-dimethoxy-2-hydroxyxanthone, a natural product with potential activity on erectile
Highly enantioselective conjugate addition of nitroalkanes to enones catalyzed by cinchona alkaloid
A pharmacological model reveals biased dependency on PI3K isoforms for tumor cell growth
Wang Y, Xu Z, Ai J, Peng X, Lin J, Ji Y, Geng M*, Long Y*. Investigation on the 1,6-naphthyridine mo
Feng JM, Miao ZH*, Jiang Y, Chen Y, Li JX, Tong LJ, Zhang J, Huang YR, Ding J*. The Conversion Betwe
Kv1.2 potassium channel inhibitors from Chukrasia tabularis
Transition metal-free one-pot synthesis of 2-substituted 3-carboxy-4-quinolone and chromone derivati
Fluevirosines A-C: A Biogenesis Inspired Example in the Discovery of New Bioactive Scaffolds from Fl
Structure-based optimization of the piperazino-containing 1,3-disubstituted ureas affording sub-nano
Pseudolaric acid B-driven phosphorylation of c-Jun impairs its role in stabilizing HIF-1alpha: a nov
Oligomannurarate sulfate sensitizes cancer cells to doxorubicin by inhibiting atypical activation of
Discovery of Novel 2-N-Aryl-Substituted Benzenesulfonamidoacetamides: Orally Bioavailable Tubulin Po
Chemical constituents from Brucea javanica
Novel 5-(benzyloxy)pyridin-2(1H)-one derivatives as potent c-Met inhibitors
MT119, a new planar-structured compound, targets the colchicine site of tubulin arresting mitosis an
Natural Product Triptolide Mediates Cancer Cell Death by Triggering CDK7-Dependent Degradation of RN
Repositioning HIV-1 Integrase Inhibitors for Cancer Therapeutics: 1,6-Naphthyridine-7-carboxamide as
O-Linked Triazolotriazines: Potent and Selective c-Met Inhibitors
The role of histone deacetylase 7 (HDAC7) in cancer cell proliferation: regulation on c-Myc
Angustimine and Angustifolimine: Two New Alkaloids from Daphniphyllum angustifolium
Synthesis toward the Lindenane-type Sesquiterpenoid Monomer of Chlorahololide A
蛋白酪氨酸激酶小分子抑制剂的研究新进展
基于配体结构的Grb2-SH2抑制剂的结构优化：更高的活性、更少的电荷、更低的肽性
人类可溶性环氧化物水解酶抑制剂的研究进展
丁健的项目
端粒酶各组分在肿瘤细胞分化过程中的表达和调控研究
期刊论文 1
抗肿瘤新药沙尔威辛分子作用机制的深入研究
期刊论文 8
针对分子靶点的抗肿瘤药物发现及其机理研究
期刊论文 58
免疫稳态失衡在炎癌转化的开关机制-免疫负性调控因子SIRPα在免疫球蛋白受体pIgR免疫背叛中的调控
中国药学科学发展战略第一届中青年学术研讨会
药理学“十三五”学科发展战略研究
针对分子靶点的抗肿瘤药物发现及其机理研究
期刊论文 6
土槿皮乙酸对新生血管生成和微管抑制作用分子机制的深入研究
期刊论文 3 会议论文 3 获奖 10
与美国癌症研究协会联合举办第二届“癌症研究新视野”大会
端粒酶在肿瘤细胞凋亡过程中的分子调控机制研究
期刊论文 3 会议论文 1
端粒酶模型的建立及其在肿瘤药理研究中的应用
期刊论文 2