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中文摘要：
中草药肾病(CHN)是一种以肾小管萎缩和肾功能衰竭为主要症状的严重疾病。近年来国内外的研究表明服用含有马兜铃酸的中药材是导致该疾病的主要原因。马兜铃酸是一种具有硝基菲羧酸的混和物,主要含马兜铃酸I(AA-I)和马兜铃酸II(AA-II)两种成分，存在于许多中药材中。本项目拟研究中药材和制剂中马兜铃酸含量的快速、高通量分离检测方法，包括HPLC、LC-MS、CE和CE-MS；发展适用于体液和肾组织细胞的样品处理方法，特别是开发马兜铃酸及其代谢产物的在线富集方法，实现体液和组织中马兜铃酸及其代谢产物的高效、高灵敏度分离检测；在此基础上，研究马兜铃酸与蛋白质的相互作用，为马兜铃酸的毒理学研究提供可靠的实验技术和基础数据。与此同时，研究建立马兜铃属类中药材的指纹图谱，为临床安全用药提供质量控制技术。
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期刊论文
Study on Separation of Aristolochic Acid I and II by Micellar Electrokinetic Capillary Chromatograph
Separation of hydrophobic solutes by organic-solvent-based micellar electrokinetic chromatography us
Study of the metabolism on tobacco-specific N-nitrosamines in the rabbit by solid-phase extraction a
Rapid determination of C12 – C26 non-derivatized fatty acids in human serum by fast gas chromatograp
Online Concentration of Aristolochic Acid I and II in Chinese medicine preparation by Micellar Elect
Fragmentation study and analysis of benzoylurea insecticides and their analogs by liquid chromatogra
Analysis of aristolochic acids by capillary electrophoresis - mass spectrometry with carboxymethyl c
Determination of Evodiamine and Rutecarpine in Human Serum by Liquid Chromatography – tandem Mass Sp
CE-MS analysis of heroin and its basic impurities using charged polymer-protected gold nanoparticles
A study of the interaction between enantiomers of zolmitriptan and hydroxypropyl-beta-cyclodextrin b
Analysis of Natural Carbohydrate Biopolymer-High Molecular Chitosan and Carboxymethyl Chitosan by Ca
Determination of tobacco-specific N-nitrosamines in rabbit serum by capillary zone electrophoresis a
Application of nanomaterials in liquid chromatography: The opportunity for separation with high effi
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