中文摘要：

目的探讨中国汉族特应性皮炎（AD）患者同时患有过敏性鼻炎（allergic rhinitis，AR）、哮喘（asthma，AS）等疾病时对AD表型的影响。方法利用2001年11月-2010年5月收集的4757例AD患者资料，采用SPSS20．0软件进行卡方检验，分析不同过敏史对AD表型的影响。结果①AD同时患有AR与南方地区（P=1．51×10^-18）正相关，与伴发耳廓下裂隙（P=1．75×10^-7）负相关，与其他表型无关；②AD同时患有AS与南方地区（P=4．39×10^-20）、掌纹症（P=5．06×10^-9）、眶周黑晕（P=3．10×10^-7）正相关，与伴发干皮症（P=2．13×10^-6）、早牟发病（P=1．35×10^-3）、耳廓下裂隙（P=1．35×10^-4）负相关，与其他表型无关；③AD同时患有AR＋AS与南方地区（P=2．76×10^-13）、伴发掌纹症（P=1．70×10^-5）、眶周黑晕（P=2．42×10^-5）正相关，与其他表型无关；④AD伴过敏家族史与毛周角化症（P=1．46×10^-3）、耳廓下裂隙（P=3．34×10^-5）正相关，与南方地区（P=4．63×10^-32）负相关，与其他表型无关。结论AD伴发不同过敏史与不同地域有关，同时影响伴发症状的发生。

英文摘要：

Objective To investigate the associations between allergic rhinitis （ AR）, asthma （AS） or other allergic history and phenotype of atopic dermatitis （AD） in the Chinese Han population. Methods Data from 4 757 AD patients collected from November 2001 to May 2010 were used in the study. SPSS 20. 0 software was used for chi-square test to determine the associations between allergic history and phenotype of AD. Results AD accompanied with AR was positively correlated with southern region （P = 1.51 ×10^-18） ,negatively associated with auricular fissure （ P = 1.75×10^-7 ）, and independent of other phenotypes. AD accompanied with AS was positively correlated with southern region （ P = 4. 39 ×10^-20 ）, palmar hyperlinearity （ P = 5.06 ×10^-9） and orbital darkening （P = 3.10 ×10^-7） ,but negatively correlated with xeroderma （P = 2. 13×10^-6） ,early onset （P = 1.35 ×10^-3 ）and auricular fissure （P = 1.35×10^-4） ,and independent of other phenotypes. AD accompanied with AR ＋ AS was positively associated with southern region （ P = 2. 76 ×10^-13 ）, palmar hyperlinearity （P = 1.70 ×10^-5 ） and orbital darkening （ P = 2. 42 ×10^-5 ）, and independent of other phenotypes. AD accompanied with family atopic history was positively correlated with ichthyosis （P = 1.46 ×10^-3） and keratosis pilaris （P = 3.34×10^-5 ） , negatively correlated with southern region （P = 4. 63 ×10^-32 ） , and independent of other phenotypes. Conclusion Allergic history is associated with multiple factors of AD,including region, and some secondary characteristics.