中文摘要：

在哺乳动物中，RNA结合蛋白Musashi（Msi）1和Msi2共同组成了Msi家族。其中，Msi2主要分布于神经、造血、胃肠、胰腺和上皮组织干细胞内，其在维持干细胞增殖和分化的平衡、调控干细胞的生长发育中起关键作用。该蛋白的表达改变会通过多种信号通路诱导恶性肿瘤的发生发展。Msi2的深入研究将为相关肿瘤提供预测标志及治疗靶点。

英文摘要：

In mammals, there are two RNA-binding proteins, Musashi （Msi）1 and Msi2, constituting the Msi family. Msi2 is mainly distributed among neural, hematopoietic, gastrointestinal, pancreatic and epithelial stem cells. It is of great importance to maintain the balance between proliferation and differentiation of stem cells and regulate their growth and development. The changed expression of this protein will induce genesis and progression of malignant tumor through many kinds of signal pathways. Thus, Msi2 is trusted to provide a predictive mark and a therapeutic target for related tumors.