位置：成果数据库 > 期刊 > 期刊详情页
An Effective Synthesis of Indazolo[2,1-a]indazole-6,12-diones by Regioselective Copper-Catalyzed Cascade Acylation/Coupling Cyclization Process
  • ISSN号：1001-604X
  • 期刊名称：《中国化学：英文版》
  • 分类：O621.3[理学—有机化学;理学—化学] O625.322[理学—有机化学;理学—化学]
  • 作者机构：[1]School of Petrochemical Engineering, Changzhou University, Changzhou, Jiangsu 213164, China, [2]Department of Chemtstry, Xtxt Campus, Zhejiang University, Hangzhou, Zhejiang 310028, China
  • 相关基金：Project supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions, the National Natural Science Foundation of China （Nos. 21072168, 21102009） and Natural Science Foundation of Jiangsu Province （No. BK2011230）.
作者： 王治明[1], 于斌[1], 崔源[1], 孙小强[1], 包伟良[2]
关键词： 区域选择性, 有效合成, 铜催化, 二酮, 酰化, 级联, 进程, 环化, Indazolone derivatives, cascade reaction, copper（I） catalyst, 2-halobenzoyl chlorides
中文摘要：

indazolo 的新、有效的串联合成[2,1-a ] indazole-6,12-diones 被开发了。这个协议包括联合反应的催化铜的 intramolecular CN 跟随的分子间的 N-acylation。方法论被用于大量 2-bromo 和 2-chloro benzoyl 氯化物产出 indazolo-[2,1-a ] indazole-6,12-diones 在对有高 regioselectivities 的优秀收益好。

英文摘要：

A new and efficient cascade synthesis of indazolo[2,1-a]indazole-6,12-diones has been developed. This protocol includes an intermolecular N-acylation followed by a copper-catalyzed intramolecular C--N coupling reaction. The methodology is applied to a wide range of 2-bromo and 2-chloro benzoyl chlorides to yield the indazolo- [2,1-a]indazole-6,l 2-diones in good to excellent yields with high regioselectivities.

同期刊论文项目
脯氨酸型手性膦有机小分子催化剂的设计、合成及其在不对称合成中的应用研究
期刊论文 12
碳氢活化、廉价金属盐催化的偶联反应等多种反应组合的一锅法串联反应研究
期刊论文 21
同项目期刊论文
Cu2O-catalyzed tandem ring-opening/coupling cyclization process for the synthesis of 2,3-dihydro-1,4
CU2O-catalyzed Ullmann-type reaction of vinyl bromides with imidazole and benzimidazole
An effective synthesis of bromoesters from aromatic aldehydes using tribromide ionic liquid based on
Stereo-selective synthesis of cis-alkenes/halo-alkenes by reaction of diphenylmethane with ethynylbe
Palladium-Catalyzed Oxidative Intramolecular C-C Bond Formation via Double sp(2) C-H Activation betw
Imidazobenzothiazine and primidobenzothiazine derivatives synthesis via an aliphatic S(N)2 substitut
Copper-Catalyzed Cascade Acylation/Coupling Cyclization Process for the Synthesis of Polycyclic Fuse
Synthesis of Unsymmetrical 2,2 '-Biindolyl Derivatives by a Cu-Catalyzed N-Arylation/Pd-Catalyzed Di
DDQ促进的无金属催化的1,3二苯丙烯与醇偶联生成C-O键
Cu-催化的N芳基化/Pd-催化的直接芳基化合成不对称2,2‘-联二吲哚衍生物
通过Cu催化的C-N偶联和Pd催化的C-H活化串联反应合成6H-isoindolo[2,1-a]indol-6-ones
钯催化的分子内咪唑2-位与苯环间的双C-H活化形成C-C键的反应
经SN2取代/Cu(I)催化的Ullmann偶联串联反应合成Imidazobenzothiazine和Primidobenzothiazine衍生物
经无配体一价铜催化的加成/环化一锅法串联反应合成Benzoxazine和1,3-oxazine衍生物
铁盐促进的二苯甲烷与苯乙炔的C-H活化偶联反应合成cis-烯烃/卤代烯烃
Synthesis of benzoxazine and 1,3-oxazine derivatives via ligand-free copper(I)-catalyzed one-pot cas
A DDQ-promoted metal-free cross-coupling of 1,3-diarylpropynes with hydroxyl via Sp(3) C-H bond acti
Synthesis of 6H-isoindolo[2,1-a]indol-6-ones through a sequential copper-catalyzed C-N coupling and
Copper-Catalyzed Cascade Acylation/Coupling Cyclization Process for the Synthesis of Polycyclic Fused Imidazo[2,1 -b] [1,3]th iazi n ones
FeCl3·6H2O？Catalyzed Intramolecular Allylic Amination: Synthesis of Substituted Dihydroqu
An Effective Synthesis of Indazolo[2,1-a]indazole-6,12-diones by Regioselective Copper-Catalyzed Cas
Metal-free synthesis of allylic amines by cross-dehydrogenative-coupling of 1,3-diarylpropenes with
Nucleophilic Phosphine Organocatalysis: a Practical Synthetic Strategy for the Drug-Like Nitrogen He
Phosphine catalysis of allenes with electrophiles
FeCl3 center dot 6H(2)O-Catalyzed Intramolecular Allylic Amination: Synthesis of Substituted Dihydro
新型含膦五元杂环类化合物的合成
Copper-Catalyzed Cascade Acylation/Coupling Cyclization Process for the Synthesis of Polycyclic Fused Imidazo[2,1 -b] [1,3]th iazi n ones
期刊信息
  • 《中国化学：英文版》
  • 主管单位:
  • 主办单位:中国化学会
  • 主编：
  • 地址：上海市枫林路354号中科院上海有机化学研究所
  • 邮编：200032
  • 邮箱：
  • 电话：021-54925243
  • 国际标准刊号：ISSN：1001-604X
  • 国内统一刊号：ISSN：31-1547/O6
  • 邮发代号:4-646
  • 获奖情况:
  • 中国期刊方阵“双高”期刊
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,荷兰文摘与引文数据库,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,英国英国皇家化学学会文摘
  • 被引量:175