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Copper-Catalyzed Cascade Acylation/Coupling Cyclization Process for the Synthesis of Polycyclic Fused Imidazo[2,1 -b] [1,3]th iazi n ones
  • ISSN号：1001-604X
  • 期刊名称：《中国化学：英文版》
  • 分类：TQ225.52[化学工程—有机化工] X132[环境科学与工程—环境科学]
  • 作者机构：[1]School of Petrochemical Engineering, Changzhou University, Changzhou, Jiangsu 213164, China, [2]Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou, Zhejiang 310028, China, [3]High Technology Research Institute of Nanjing University, Changzhou, Jiangsu 213164, China
  • 相关基金：Project supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions, the National Natural Science Foundation of China （Nos. 21072168, 21102009） and Natural Science Foundation of Jiangsu Province （No. B K2011230）.
作者： 王治明[1], 于斌[1], 张秀芹[3], 孙小强[1], 包伟良[2]
关键词： 多环芳烃, 铜催化, 咪唑, 合成, 酰化, 级联, 环化, 耦合, fused heterocycles, cascade reaction, copper（I） catalyst, 2-halobenzyl chlorides, 2-mercaptoimidazole
中文摘要：

多不的熔化 imidazo 的新、有效的串联合成[2,1-b ][1,3 ] thiazinones 被开发了。这个协议包括联合反应的催化铜的 intramolecular CS 跟随的分子间的 N-acylation。方法论被用于大量 2-iodo， 2-bromo，和产出多不的熔化 imidazo 的 2-chloro benzoyl 氯化物[2,1-b ][1,3 ] thiazinones 在对优秀收益好。

英文摘要：

A new and efficient cascade synthesis of polycyclic fused imidazo[2,1-b][1,3]thiazinones has been developed. This protocol includes an intermolecular N-acylation followed by a copper-catalyzed intramolecular C--S coupling reaction. The methodology is applied to a wide range of 2-iodo, 2-bromo, and 2-chloro benzoyl chlorides to yield the polycyclic fused imidazo[2,1-b][ 1,3]thiazinones in good to excellent yields.

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期刊信息
  • 《中国化学：英文版》
  • 主管单位:
  • 主办单位:中国化学会
  • 主编：
  • 地址：上海市枫林路354号中科院上海有机化学研究所
  • 邮编：200032
  • 邮箱：
  • 电话：021-54925243
  • 国际标准刊号：ISSN：1001-604X
  • 国内统一刊号：ISSN：31-1547/O6
  • 邮发代号:4-646
  • 获奖情况:
  • 中国期刊方阵“双高”期刊
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,荷兰文摘与引文数据库,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,英国英国皇家化学学会文摘
  • 被引量:175