中文摘要：

银屑病是一种以Th17淋巴细胞异常活化和浸润为主要特征的慢性炎性反应皮肤病。调节Th17迁移的趋化因子/趋化因子受体CCL20/CCR6轴在银屑病的发病机制中可能处于关键地位,因而成为新的治疗靶标。CCL20/CCR6轴异常表达,导致Th17细胞异常迁移,并激活Th17细胞与角质形成细胞间的循环刺激网络,是银屑病皮损炎症反应持续存在的重要基础。

英文摘要：

Psoriasis is a chronic inflammatory skin disease characterized by abnormal activated Th17 cells infiltration. Recently, chemokine/chemokine receptor （CCL20/CCR6） axis has being recognized as a key player and potential therapeutic target in psoriasis. Abnormal CCL20/CCR6 expressions lead to chemotaxis of Th17 cells and the formation of stimulation loop between Th17 cells and keratinocyte, which has been considered as the main cause of persist inflammation in psoriasis lesions.