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中文摘要：
简要介绍了聚N-异丙基丙烯酰胺（P01y N—isopropylacrylamide，PNIPA）类纳米水凝胶的性质及智能响应机理，并重点综述了近年来此类纳米水凝胶在药物缓控释研究中的应用：作为脂溶性小分子药物的载体，达到增溶及缓控释药物的效果，并增强药物婶稳定性及生物活性；作为水溶性小分子药物的载体，达到缓释该类药物的效果；作为生物大分子药物（蛋白，多糖）的载体，克服直接用药时的弊端；此外，还可作为基因工程载体。
英文摘要：
In this article, the properties and the responsive mechanism of PNIPA nano-hydrogels were briefly introduced. And then more emphasis was placed on the application of PNIPA nano-hydrogels as drug carriers for controlled and sustained drug release. They provide liposoluble drugs with stability, solubility, bioaetivity. And hydrosoluble drugs entrapped in PNIPA nano-hydrogels can be sustainedly released. They can also be used as carriers for biomacromoleeule drags to avoid disadvantage in application. PNIPA nano-hydrogels are also favourable gene engineering carriers.
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