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DISC1Ser704Cys基因型与脑白质完整性无显著性相关：一项中国较大样本的影像遗传学研究
  • 时间：0
  • 分类：R394[医药卫生—医学遗传学;医药卫生—基础医学]
  • 作者机构：[1]中国科学院自动化研究所模式识别国家重点实验室LLAMA计算医学中心,北京100019, [2]叶1圈科学院计算机技术研究所国家高性能计算技术研究中心,北京100019, [3]天津医科大学总医院放射科,天津300052, [4]电子科技大学生命科学与技术学院神经信息教育部重点实验室,成都610054, [5]澳大利亚昆七兰大学昆士兰脑研究所,BrisbaneQLD4072,Australia
  • 相关基金：support from the National Key Basic Research and Devdopment Program(973),Grant No.2011CB707805;the Natural Science Foundation of China,Grant Nos.81000582 and 60831004;the National High Technology Research and Development Program of China(863 Program), Grant No.2009AA02Z302;The Beijing Nova Program,Grant No.2010B061
作者： 刘冰[1], 李永辉[1,2], 侯冰[1], 于春水[3], 蒋田仔[1,4,5]
关键词： 精神分裂症, 弥散磁共振影像, Disrupted-in-Schizophrenia-1(DISC1), 基于纤维束骨架的空间统计分析, 白质完整性
中文摘要：

近来一项87例英国健康人群的影像遗传学研究，报告了DISCISer704Cys显著调控脑内的大范围的白质完整性。然而．此类研究的结果在独立样本中的可重复性尤其重要。我们用一组较大样本的健康中国汉族人群，同时采集了遗传学资料和弥散磁共振影像学数据，然后开展了同样的基于纤维束骨架的空间统计分析（TBSS分析）研究，然后在我们的样本中没有发现DISCISer704Cys与白质完整性的任何显著性相关。我们的研究结果不支持在中国汉族人群中的DISCISer704Cys与脑白质完整型的显著性关联。因此，此相关很有必要在更进一步独立样本中的验证。

英文摘要：

One recent study from a population of 87 healthy UK subjects has reported a significant association of white matter integrity with DISCI Ser704Cys. Such association is rather impressive, but replication studies in independent populations are necessary. With a large sample of 278 healthy Han Chinese subjects, we carried out the same analyses to test the association of white matter integrity with DISC Ser704Cys, but did not find any significant association. Our results do not support the association between white matter integrity measured by tract-based spatial statistics ( TBSS) method and DISCI Ser704Cys, at least in the Han Chinese population. More replication studies in different population are desired to further test the association.

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