中文摘要：

背景成功的老化( SA )和温和认知缺陷(媒体控制接口)是 aging.To 的异构的组探索异质，功能的连接在现在的学习利用了的这些 populations.Methods 被学习功能的连接磁性的回声成像( fcMRI ) 8 平常的老化( UA )使遭到在 SA 的 8 个健康题目，调查缺省模式网络( DMN )，并且 8 个媒体控制接口病人在口头的流利测试( VFT )期间，不同的组的 .Functional 连接(基于的种子)是分析

英文摘要：

Background Successful aging （SA） and mild cognitive impairment （MCI） are heterogeneous groups of aging.To explore the heterogeneity,the functional connectivity was studied in these populations.Methods The present study utilized functional connectivity magnetic resonance imaging （fcMRI） to investigate default mode network （DMN） in 8 healthy subjects of SA,8 subjects of usual aging （UA）,and 8 MCI patients during verbal fluency tests （VFTs）.Functional connectivity （based seeds） of different groups was analyzed by using statistical test.Results Compared with SA and UA groups,MCI subjects exhibited decreased functional connectivity in the DMN regions,including the inferior parietal Iobule and left angular gyrus （t=3.53,P 〈0.001）.Compared with UA and MCI groups,the SA elderly exhibited increased functional connectivity in the precuneus （t=3.53,P〈0.001）.Conclusions These findings suggested that abnormalities of functional connectivity in DMN might be related with semantic memory impairment in aging.Left angular gyrus and precuneus might be the potential imaging-based biomarker for distinguishing heterogeneous process of elderly.