中文摘要：

目的：探讨光学相干断层成像技术（OCT）对釉质早期龋的成像和量化评估效能，为其在早期龋临床诊断中的应用提供实验依据。方法采用OCT扫描牛牙光滑面早期人工龋模型和脱矿模型，获取釉质图像和光学信息，并与偏振光显微镜图像和原子吸收光谱测得的矿质损失量进行对比，采用SPSS软件包配对t检验和Pearson相关性分析进行数据分析。结果 早期龋及脱矿釉质OCT图像与偏光显微镜图像基本相符；OCT测得的早期龋组釉质的总反射率改变量低于脱矿组（P＜0.05），脱矿深度在两组间无统计学差异（P＞0.05）。釉质总反射率改变量与矿质损失量呈正相关（P＜0.05）。结论 OCT能够无创地、较准确地显示釉质早期龋的矿质改变，量化其病变范围和程度，在早期龋的临床诊断方面具有广阔的应用前景。

英文摘要：

Objective To explore the efficacy of optical coherence tomography （OCT） in imaging and quantitatively eva- luating early enamel caries and provide experimental evidence for the clinical diagnosis of early caries. Methods The smooth surface of bovine teeth showing early artificial caries and demineralization changes was scanned by an all fiber-based OCT for images and optical profiles, which were compared with images from a polarized light microscope （PLM） and mineral loss from an atomic absorption spectrometer. Data were analyzed by paired-sample t-test and Pearson correlation analysis using SPSS software. Results The images of enamel with early caries and demineralization from OCT coincided with those from PLM. The integrated reflectivity loss in the early caries group was significantly lower than that in the demineralized group （P〈0.05）, whereas no significant difference in demineralized depth was found between the two groups （P〉0.05）. A linear correlation was observed between integrated reflectivity loss and mineral loss （P〈0.05）. Conclusion OCT can be used to nondestructively and accurately image early caries and quantify lesion extent and degree, suggesting the extensive use of this approach in the clinical diaRnosis of early caries.