中文摘要：

驱动蛋白是一类蛋白质超家族的总称，其中驱动蛋白-1（以下简称驱动蛋白）是目前已知的有机体内最小的马达蛋白．驱动蛋白能够催化三磷酸腺苷（adenosine triphosphate，ATP）分子的水解反应，将贮藏在ATP中的化学能转变为自身机械运动所需的机械能．驱动蛋白能够沿着微管连续定向运动．在细胞的有丝分裂和胞内物质运输中发挥重要作用．在真核细胞中，驱动蛋白主要以二聚体的形式存在，其结构主要包括4个部分．即马达头部、茎部、连接头部与茎部的颈链以及与“货物”相结合的尾部．驱动蛋白二聚体独特的结构特征以及各个组成部分协调的构象变化，保证了其沿微管的连续行走．目前，驱动蛋白的结构与功能之间的关系的研究取得了重要的进展．随着实验和计算水平的不断提高，彻底了解驱动蛋白的运动机理已经为期不远了．

英文摘要：

Kinesin is a protein superfamily, of which kinesin-1 （abbreviated to kinesin） is the smallest motor protein in organism known to date. Kinesin catalyzes adenosine triphosphate （ATP） hydrolysis and converts the released chemical energy into mechanical energy for its successive movement along microtubule, which is crucial for mitosis and organelle transportation in cells. In eukaryotic cells, kinesin exists as a dimer. It consists of four parts including the motor head, stalk, neck linker that connects the head and the stalk and the tail that binds the cargo. Kinesin＇s unique structure and the exquisite cooperation between its structural elements ensure its processive walk along microtubule. The investigation on the structure-function relation-ship of kinesin has made important progress. Along with the fast development of experiment and computation condition, it can be anticipated that a thorough understanding of the mechanism underlying kinesin move-ment is not far away.