中文摘要：

目的：观察芪白平肺胶囊对慢性阻塞性肺疾病（COPD）痰瘀阻肺证模型大鼠血清缺氧诱导因子-1α（HIF-1α）、血小板衍生生长因子（PDGF）表达的影响。方法：复制COPD痰瘀阻肺证大鼠模型,给予芪白平肺胶囊、法舒地尔干预,ELISA检测模型大鼠HIF-1α、PDGF表达。结果：模型组PDGF、HIF-1α表达水平较正常组明显升高（P〈0.01）;芪白平肺胶囊低剂量组PDGF、HIF-1α表达水平较正常组显著升高（P〈0.05）;芪白平肺胶囊低、高剂量组PDGF、高剂量组HIF-1α表达水平较模型组明显降低（P〈0.05,P〈0.01）;芪白平肺胶囊低剂量组PDGF表达水平较芪白平肺胶囊高剂量组显著降低（P〈0.05）。结论：芪白平肺胶囊可降低COPD痰瘀阻肺证模型大鼠血清PDGF、HIF-1α表达水平。

英文摘要：

Objective： To observe the influence of Qibai Pingfei Capsule on hypoxia inducible factor-α （HIF-1α） and platelet-derived growth factor （PDGF） in serum of chronic obstructive pulmonary disease （COPD） rats with syndrome of phlegm and blood stasis obstructing lung. Method： COPD rat model with syndrome of phlegm and blood stasis obstructing lung was established and intervened with Qibai Pingfei Capsule and fasudil. The expression of PDGF and HIF-1α in serum of rat models was determined by using ELISA method. Methods： The expression of PDGF and HIF-1α of rats in model group and low dosage of Qibai Pingfei Capsule group was higher than that of control group （P〈0.01, P〈0.05）. The expression of PDGF and HIF-1α of rats in low and high dosage of Qibai Pingfei Capsule group was lower than that of rats in model group （P〈0.05, P〈0.01）, and the expression of PDGF and HIF-1α of rats in low dosage of Qibai Pingfei Capsule group was lower than that of high dosage of Qibai Pingfei Capsule group （P〈0.05）. Conclusion： Qibai Pingfei Capsule could reduce the expression of PDGF and HIF-1α in serum of COPD rats with syndrome of phlegm and blood stasis obstructing lung.