中文摘要：

研究宫内发育迟缓（intra-uterine growth retardation,IUGR）对哺乳仔猪血液生理生化指标、胰腺质量及其分泌酶活性的影响,以及日粮添加0.1%三丁酸甘油酯对其调控作用。选取8头正常初生体质量仔猪和16头IUGR仔猪,将IUGR仔猪随机均分为2组,分别饲喂基础人工乳（IUGR组）、基础人工乳＋0.1%三丁酸甘油酯（IUGR＋tributyrin,IT组）,正常仔猪饲喂基础人工乳（NBW组）。7日龄开始饲喂,21日龄时每组选取6头体质量相近的仔猪屠宰取样,并对血液指标和胰腺酶活力进行测定。结果表明：1）受IUGR影响,仔猪血液中尿素、总胆红素含量显著降低（P〈0.05）,总蛋白、肌酐含量显著上升（P〈0.05）;胰腺质量也较NBW组显著降低（P〈0.05）;胰淀粉酶、脂肪酶活力显著降低（P〈0.05）。2）IUGR仔猪日粮补充0.1%三丁酸甘油酯后,血液中尿素、总胆红素、总蛋白、肌酐与NBW组相比,均无显著差异（P〉0.05）;且胰腺质量得到增加（P〉0.05）,胰蛋白酶、胰淀粉酶和脂肪酶含量均显著提高（P〈0.05）。结果提示：IUGR可对哺乳仔猪血液生理生化造成一定的影响和阻碍胰腺的发育以及酶活性的分泌,日粮补充0.1%三丁酸甘油酯能对IUGR造成的损伤有一定的缓解作用。

英文摘要：

The main objective of this experiment was to evaluate the regulatory effect of dietary supplementation of tributyrin at 0.1% on blood physiological and biochemical indexes, pancreas weight, and pancreatic enzyme secretion in sucking piglets with intrauterine growth retardation（IUGR）. Totally 8 normal-birth-weight piglets and 16 IUGR piglets were selected. The IUGR piglets were randomly divided into 2 groups（IUGR group was fed basic artificial milk; IUGR＋tributyrin group fed basic artificial milk supplemented with 0.1% tributyrin）. The normal-birth-weight piglets fed with basic artificial milk（NBW group）. The experiment started from 7 days and ended at 21 days of age. Then, 6 piglets with nearly equal body weight were selected from each group and slaughtered. Blood parameters and pancreatic enzyme activities were detected. The results showed that the levels of blood total bilirubin and urea were significantly decreased（P 〈 0.05）, and total protein and creatinine were significantly increased（P 〈 0.05） in IUGR piglets. The pancreas weights of IUGR piglets were significantly lower（P 〈 0.05） than those of the NBW group. Pancreatic amylase and lipase activities in IUGR piglets were significantly decreased（P 〈 0.05）. Moreover, after being supplemented with 0.1% tributyrin, blood urea, total bilirubin, total protein and creatinine in IUGR piglets had no significant difference（P 〉 0.05） from those in the NBW group. Pancreas weight was increased（P 〉 0.05）, trypsin, amylase and lipase were significantly increased（P 〈 0.05） in IUGR piglets. The above findings suggested that blood physiological and biochemical indices of sucking piglets could be influenced by IUGR. Dietary supplementation of 0.1% tributyrin has a potential therapeutic role in attenuating the damage caused by IUGR.