中文摘要：

采用病例-家系对照和随机病例-对照两种设计，分析了603例样本脂联素基因（Adiponectin，APMI）单核苷酸多态性（SNP）rs13061862（T45G）与湖北汉族人群2型糖尿病的相关性。在所有样本中，2型糖尿病病人的G等位基因及GG基因型频率显著高于正常人（G：42．0％比21．7％，P〈0．001；GG：13．6％比4．5％，P=0．032）；在180个病例-家系对照中，2型糖尿病患者的GG基因型频率显著高于对照组（GG：17．8％比5．6％，P=0．011）；在423个随机病例-对照中，2型糖尿病患者GG基因型频率也显著高于对照组（GG：12．2％比3．9％，P=0．025）；单因素Logistic回归分析显示，GG基因型是2型糖尿病的危险因子（OR=3．58，95％CI=1．70—7．54）。这些结果表明，脂联素基因SNPT45G多态性与湖北汉族人群2型糖尿病的发生发展相关，GG基因型是中国湖北汉族人2型糖尿病的遗传危险因素。

英文摘要：

To investigate the association between the APMI SNP rs 13061862 and type 2 diabetes mellitus （T2DM）, a total of 603 Han subjects from Hubei Province were genotyped for the APMI SNP T45G. Both family-based casecontrol and unrelated case-control designs were used. The frequencies of the G allele and GG genotype for T2DM patients were significantly higher than those for controls （G： 42.0% vs. 21.7%, P〈0.001; GG： 13.6% vs. 4.5%, P= 0.032） in all subjects. The GG genotype was associated with higher risk of T2DM in family-based case-control groups （GG： 17.8% vs. 5.6%, P = 0.011）, while the G allele and GG genotype for T2DM patients were significantly higher than those for controls in the unrelated case-control groups （GG： 12.2% vs. 3.9%, P = 0.025）. Logistic regression analysis suggested that GG genotype was the genetic risk factors for T2DM （OR = 3.58, 95% CI=1.70-7.54）. In conclusion, the APMI SNP T45G is associated with T2DM risk, and the GG genotype may be a genetic risk factor of T2DM in Han population of Hubei Province.