中文摘要：

目的：探讨胰岛素受体基因（INSR）的第8外显子NaiⅠ多态性与湖北汉族人群2型糖尿痛的相关性；方法：采用同胞对（家系内对照）和随机病例-对照两种实验设计，并结合聚合酶链反应-限制性片断长度多态性（PCR—RFLP）技术分析了224个样本的INSR基因第8外显子NsiⅠ多态性，并洲定了身高、体重、腰围、臀围、血压和空腹血糖等生理指标；结果：两种实验设计中对照组与病例组的基因型和基因频率均无显著差异；结论：INSR基因在湖北汉族人群2型糖屎病的发生发展中可能不起主要作用。

英文摘要：

Objective： To investigate the correlation between insulin receptor （INSR） gene Nsi Ⅰ polymorphism of exon 8 and type 2 diabetes mellitus in Hubei Han people. Methods： Both sib - pairs and random case - control designs were used. The genotypes in 224 samples were examined using polymerase chain reaction- restriction fragment length polymorphism （PCR- RFLP）. Height, weight, blood pressure and fasting blood glucose were measured. Results： In two experimental designs, there were no significant differences in the genotype and gene frequency between cases and controls. Conclusion： Type 2 diabetes mellitus may be little associated with INSR gene Nsi Ⅰ polymorphism of exon 8 in Hubei Han people.