中文摘要：

探讨以药物丹参素处理骨髓间质干细胞（MSCs）后，移植大鼠心梗的治疗作用。运用结扎SD大鼠冠脉前降支制备心梗模型，将体外培养并以丹参素处理过的MSCs注射到心梗模型的缺血区。随机将实验动物分为：MI＋Saline、MI＋MSC、MI＋MSC＋SAA、MI＋sAA和Sham5组。分别观察术后3d、4周大鼠的心功能和组织病理变化，Westernblot测定BAX、BCL-2、MMP-9、TIMP-1、IL-6、IL-10、COX-2和VEGF等指标的表达水平。实验结果显示各项检测结果均显示MI＋MSC＋SAA（丹参素）的治疗效果明显的优于其他各组（P〈0.01）。实验结果表明，经处理后的骨髓间质干细胞（MsCs）可以在心梗区定植，促进心肌和血管生成，提高左室收缩和舒张功能，还可以有效地抑制炎性反应和心室重塑从而达到治疗效果。

英文摘要：

This study was performed to investigate the feasibility and efficiency of exoge-nous mesenchymal stem cells （MSCs, pretreated by Salvianic Acid A, SAA） transplantation on post-infarction ventricular remodeling, inflammatory reaction and heart function in rats. Rats were randomly divided into 5 groups：MI＋Saline, MI＋SAA, MI＋MSC, MI＋MSC＋SAA, and Sham. The left anterior descending coronary artery of the SD rat was ligated in order to induce myocardial infarction. MSCs cultured in vitro and pretreated by SAA was injected to the ischemic region of the myocardial infarction model. For the following 3 days and 4 weeks after the treatment, the eardiac function was examined. The expression level of index, such as BAX, BCL-2, MMP-9, TIMP-1, IL-6, IL-10, COX-2 and VEGF, were analyzed by means of Western blot. MSCs transplantation decreased LV end-diastolic diameter and end-systolic diameter,limited LV chamber dilatation significantly. The expression of MMP-9 and TIMP-1 showed that the accumulation of the collagen was most severe in the MI＋Saline group and greatly deereased in the groups of drug therapy. The expression of BAX and BCL-2 suggested that the SAA treated MSCs could inhibit apoptosis in cardiomyocytes. All the results reveal that the therapy effect of group MI＋MSC＋SAA is obviously superior to the other groups （p〈0.01）. It is concluded that transplantation of SAA pretreated MSCs can effectively inhibit inflammatory reaction in the myocardial infarction area, and improve the left ventricular diastolic function and systolic function. Treatment of MSCs with SAA may be a new approach that enhances the therapeutic performance of MSCs in myocardium repair.